TY - JOUR
T1 - Effect of chitosan on lingual hemostasis in rabbits
AU - Klokkevold, Perry R.
AU - Lew, Douglas S.
AU - Ellis, Duncan G.
AU - Bertolami, Charles N.
N1 - Funding Information:
Received from the School of Dentistry, University of California, Los Angeles. * Adjunct Assistant Professor, Section of Hospital Dentistry. t Resident, Section of Hospital Dentistry. $ Section of Oral and Maxillofacial Surgery. I Chairman, Section of Oral and Maxillofacial Surgery. Supported by Hoechst-Roussel Pharmaceuticals Inc. Address correspondence and reprint requests to Dr Klok-kevold: UCLA School of Dentistry, 13-089 CHS, Section of Hospital Dentistry, Los Angeles, CA 90024-1668.
PY - 1991/8
Y1 - 1991/8
N2 - Bleeding times were measured for bilateral (15 mm × 2 mm) tongue incisions in 14 New Zealand white rabbits. Using a randomized, blinded experimental design, one incision in each animal was treated with chitosan and the other was treated with control vehicle without chitosan. Extraoral bleeding and coagulation times were also measured for each animal preoperatively, postoperatively, and prior to killing to verify normal bleeding parameters and to evaluate possible systemic effects associated with topical application. Comparison of lingual incisions receiving the experimental substance versus those receiving control solution showed enhanced hemostasis manifested by a 32% (P < .05) decrease in bleeding time.
AB - Bleeding times were measured for bilateral (15 mm × 2 mm) tongue incisions in 14 New Zealand white rabbits. Using a randomized, blinded experimental design, one incision in each animal was treated with chitosan and the other was treated with control vehicle without chitosan. Extraoral bleeding and coagulation times were also measured for each animal preoperatively, postoperatively, and prior to killing to verify normal bleeding parameters and to evaluate possible systemic effects associated with topical application. Comparison of lingual incisions receiving the experimental substance versus those receiving control solution showed enhanced hemostasis manifested by a 32% (P < .05) decrease in bleeding time.
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U2 - 10.1016/0278-2391(91)90017-G
DO - 10.1016/0278-2391(91)90017-G
M3 - Article
C2 - 2072198
AN - SCOPUS:0025864151
SN - 0278-2391
VL - 49
SP - 858
EP - 863
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
IS - 8
ER -