Effect of chitosan on lingual hemostasis in rabbits with platelet dysfunction induced by epoprostenol

Perry R. Klokkevold, Paul Subar, Haruhisa Fukayama, Charles N. Bertolami

Research output: Contribution to journalArticle

Abstract

Chitosan, a complex carbohydrate derivative of shellfish exoskeleton, is shown to enhance lingual hemostasis in rabbits treated with a known antagonist of platelet function, epoprostenol (prostacyclin or PGI2). Bleeding times were measured for bilateral (15 mm × 2 mm) tongue incisions in 10 New Zealand white rabbits. Using a randomized, blinded experimental design, one incision in each animal was treated with chitosan and the other was treated with control vehicle without chitosan. Extraoral bleeding and coagulation times were measured for each animal before, during, and after infusion of epoprostenol. Continuous infusion of epoprostenol increased mean systemic bleeding time 95%. In this platelet dysfunction animal model, lingual incisions receiving the experimental substance showed a 56% improvement in bleeding time in comparison with lingual incisions receiving control solution (P = .003).

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalJournal of Oral and Maxillofacial Surgery
Volume50
Issue number1
DOIs
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Effect of chitosan on lingual hemostasis in rabbits with platelet dysfunction induced by epoprostenol'. Together they form a unique fingerprint.

  • Cite this