TY - JOUR
T1 - Effect of chitosan on lingual hemostasis in rabbits with platelet dysfunction induced by epoprostenol
AU - Klokkevold, Perry R.
AU - Subar, Paul
AU - Fukayama, Haruhisa
AU - Bertolami, Charles N.
N1 - Funding Information:
Received from the School of Dentistry, University of California. Los Angeles. * Adjunct Assistant Professor and Director, Section of Hospital Dentistry. t Dental Student, School of Dentistry. $ Visiting Dental Anesthesiologist, Section of Hospital Dentistry. 0 Professor and Chairman, Section of Oral and Maxillofacial Surgery. Research supported by Hoechst-Roussel Pharmaceuticals Inc. Address correspondence and reprint requests to Dr Klokkevold: UCLA School of Dentistry, 13-089 CHS-Section of Hospital Dentistry, Los Angeles, CA 90024-1668.
PY - 1992/1
Y1 - 1992/1
N2 - Chitosan, a complex carbohydrate derivative of shellfish exoskeleton, is shown to enhance lingual hemostasis in rabbits treated with a known antagonist of platelet function, epoprostenol (prostacyclin or PGI2). Bleeding times were measured for bilateral (15 mm × 2 mm) tongue incisions in 10 New Zealand white rabbits. Using a randomized, blinded experimental design, one incision in each animal was treated with chitosan and the other was treated with control vehicle without chitosan. Extraoral bleeding and coagulation times were measured for each animal before, during, and after infusion of epoprostenol. Continuous infusion of epoprostenol increased mean systemic bleeding time 95%. In this platelet dysfunction animal model, lingual incisions receiving the experimental substance showed a 56% improvement in bleeding time in comparison with lingual incisions receiving control solution (P = .003).
AB - Chitosan, a complex carbohydrate derivative of shellfish exoskeleton, is shown to enhance lingual hemostasis in rabbits treated with a known antagonist of platelet function, epoprostenol (prostacyclin or PGI2). Bleeding times were measured for bilateral (15 mm × 2 mm) tongue incisions in 10 New Zealand white rabbits. Using a randomized, blinded experimental design, one incision in each animal was treated with chitosan and the other was treated with control vehicle without chitosan. Extraoral bleeding and coagulation times were measured for each animal before, during, and after infusion of epoprostenol. Continuous infusion of epoprostenol increased mean systemic bleeding time 95%. In this platelet dysfunction animal model, lingual incisions receiving the experimental substance showed a 56% improvement in bleeding time in comparison with lingual incisions receiving control solution (P = .003).
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U2 - 10.1016/0278-2391(92)90194-5
DO - 10.1016/0278-2391(92)90194-5
M3 - Article
C2 - 1727460
AN - SCOPUS:0026595743
VL - 50
SP - 41
EP - 45
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
SN - 0278-2391
IS - 1
ER -