Effect of endothelin on outflow facility and accommodation in the monkey eye in vivo

K. Erickson-Lamy, C. Korbmacher, J. S. Schuman, J. A. Nathanson

    Research output: Contribution to journalArticle

    Abstract

    The effect of the vasoactive peptide, endothelin, on facility of outflow, accommodation, and pupil diameter was measured in the monkey eye in vivo. Endothelin increased the outflow facility 22-71% at approximate anterior chamber concentrations ranging from 10-10-10-7 M. Endothelin-induced accommodation was modest but consistent and statistically significant ranging from 1.61 to a maximum of 2.43 diopters at 10-9 M and 10-7 M endothelin, respectively. No change in pupil diameter was noted with any of the administered doses. These data demonstrate an action of endothelin on outflow facility and, together with prior evidence indicating the presence of endothelin receptors on the ciliary muscle, suggest that, like cholinergic agonists, the observed effects of endothelin on outflow facility may be mediated, at least in part, through an action on the ciliary muscle.

    Original languageEnglish (US)
    Pages (from-to)492-495
    Number of pages4
    JournalInvestigative Ophthalmology and Visual Science
    Volume32
    Issue number3
    StatePublished - 1991

    ASJC Scopus subject areas

    • Ophthalmology
    • Sensory Systems
    • Cellular and Molecular Neuroscience

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    Erickson-Lamy, K., Korbmacher, C., Schuman, J. S., & Nathanson, J. A. (1991). Effect of endothelin on outflow facility and accommodation in the monkey eye in vivo. Investigative Ophthalmology and Visual Science, 32(3), 492-495.