Effect of folate on phenytoin hyperplasia

Howard J. Drew, Richard I. Vogel, Walter Molofsky, Herman Baker, Oscar Frank

Research output: Contribution to journalArticlepeer-review


Abstract There have been some reports that folic acid inhibits phenytoin‐induced gingival hyperplasia. The purpose of this double‐blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin‐induced gingival overgrowth in man. For a period of 6 months, one group of phenytoin patients received 2 daily topical applications of a folate solution. An additional group received 2 daily doses of systemic folate while a control group received placebo medication. Results indicate that throughout the 180‐day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.

Original languageEnglish (US)
Pages (from-to)350-356
Number of pages7
JournalJournal of clinical periodontology
Issue number6
StatePublished - Jul 1987


  • Folic acid
  • gingival hyperplasia
  • phenytoin

ASJC Scopus subject areas

  • Periodontics


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