Effect of folate on phenytoin hyperplasia

Howard J. Drew; Richard I. Vogel; Walter Molofsky; Herman Baker; Oscar Frank

doi:10.1111/j.1600-051X.1987.tb00983.x

Effect of folate on phenytoin hyperplasia

Howard J. Drew, Richard I. Vogel, Walter Molofsky, Herman Baker, Oscar Frank

Periodontology and Implant Dentistry

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract There have been some reports that folic acid inhibits phenytoin‐induced gingival hyperplasia. The purpose of this double‐blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin‐induced gingival overgrowth in man. For a period of 6 months, one group of phenytoin patients received 2 daily topical applications of a folate solution. An additional group received 2 daily doses of systemic folate while a control group received placebo medication. Results indicate that throughout the 180‐day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.

Original language	English (US)
Pages (from-to)	350-356
Number of pages	7
Journal	Journal of clinical periodontology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1111/j.1600-051X.1987.tb00983.x
State	Published - Jul 1987

Keywords

Folic acid
gingival hyperplasia
phenytoin

ASJC Scopus subject areas

Periodontics

Access to Document

10.1111/j.1600-051X.1987.tb00983.x

Cite this

@article{692b312f2ec444b3aa8e0ebb2660e4e0,

title = "Effect of folate on phenytoin hyperplasia",

abstract = "Abstract There have been some reports that folic acid inhibits phenytoin‐induced gingival hyperplasia. The purpose of this double‐blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin‐induced gingival overgrowth in man. For a period of 6 months, one group of phenytoin patients received 2 daily topical applications of a folate solution. An additional group received 2 daily doses of systemic folate while a control group received placebo medication. Results indicate that throughout the 180‐day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.",

keywords = "Folic acid, gingival hyperplasia, phenytoin",

author = "Drew, {Howard J.} and Vogel, {Richard I.} and Walter Molofsky and Herman Baker and Oscar Frank",

year = "1987",

month = jul,

doi = "10.1111/j.1600-051X.1987.tb00983.x",

language = "English (US)",

volume = "14",

pages = "350--356",

journal = "Journal of clinical periodontology",

issn = "0303-6979",

publisher = "Blackwell Munksgaard",

number = "6",

}

TY - JOUR

T1 - Effect of folate on phenytoin hyperplasia

AU - Drew, Howard J.

AU - Vogel, Richard I.

AU - Molofsky, Walter

AU - Baker, Herman

AU - Frank, Oscar

PY - 1987/7

Y1 - 1987/7

N2 - Abstract There have been some reports that folic acid inhibits phenytoin‐induced gingival hyperplasia. The purpose of this double‐blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin‐induced gingival overgrowth in man. For a period of 6 months, one group of phenytoin patients received 2 daily topical applications of a folate solution. An additional group received 2 daily doses of systemic folate while a control group received placebo medication. Results indicate that throughout the 180‐day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.

AB - Abstract There have been some reports that folic acid inhibits phenytoin‐induced gingival hyperplasia. The purpose of this double‐blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin‐induced gingival overgrowth in man. For a period of 6 months, one group of phenytoin patients received 2 daily topical applications of a folate solution. An additional group received 2 daily doses of systemic folate while a control group received placebo medication. Results indicate that throughout the 180‐day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.

KW - Folic acid

KW - gingival hyperplasia

KW - phenytoin

UR - http://www.scopus.com/inward/record.url?scp=0023372824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023372824&partnerID=8YFLogxK

U2 - 10.1111/j.1600-051X.1987.tb00983.x

DO - 10.1111/j.1600-051X.1987.tb00983.x

M3 - Article

C2 - 3305590

AN - SCOPUS:0023372824

SN - 0303-6979

VL - 14

SP - 350

EP - 356

JO - Journal of clinical periodontology

JF - Journal of clinical periodontology

IS - 6

ER -

Effect of folate on phenytoin hyperplasia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this