TY - JOUR
T1 - Effect of multi-session prefrontal transcranial direct current stimulation on cognition in schizophrenia
T2 - A systematic review and meta-analysis
AU - Narita, Zui
AU - Stickley, Andrew
AU - DeVylder, Jordan
AU - Yokoi, Yuma
AU - Inagawa, Takuma
AU - Yamada, Yuji
AU - Maruo, Kazushi
AU - Koyanagi, Ai
AU - Oh, Hans
AU - Sawa, Akira
AU - Sumiyoshi, Tomiki
N1 - Funding Information:
This study was supported by the Japan Society for the Promotion of Science KAKENHI No. 17K10321 , Intramural Research Grant (29–1, 30–1, 30–8) for Neurological and Psychiatric Disorders of the National Center of Neurology and Psychiatry , and Japan Agency for Medical Research and Development AMED, Japan under Grant Number 18dk0307069 and 18dk0307081 .
Funding Information:
This study was supported by the Japan Society for the Promotion of Science KAKENHI No. 17K10321, Intramural Research Grant (29?1, 30?1, 30?8) for Neurological and Psychiatric Disorders of the National Center of Neurology and Psychiatry, and Japan Agency for Medical Research and Development AMED, Japan under Grant Number 18dk0307069 and 18dk0307081.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/2
Y1 - 2020/2
N2 - Patients with schizophrenia experience cognitive deficits that play a central role in predicting functional outcomes. In this study, we sought to evaluate the effect of transcranial direct current stimulation (tDCS) on cognition using meta-analysis. A search was performed from inception to 8 January 2019, to identify randomized controlled trials assessing the ability of tDCS to ameliorate cognitive deficits in patients with schizophrenia and schizoaffective disorder. The effect size, calculated as the standardized mean difference (Hedge's g), was obtained with a random effect model. We analyzed mean effects on specific cognitive domains that were evaluated in four or more studies. Nine articles were included in the systematic review, which encompassed 270 patients: 133 in the active stimulation group and 137 in the sham stimulation group. Meta-analysis demonstrated a significant mean effect of tDCS on working memory (SMD = 0.49, 95% CI = 0.16 to 0.83), while non-significant results were produced for other domains. These findings were supported by sensitivity analyses indicating that the results would not change in a meaningful way after the exclusion of each single study, and meta-regression analyses verifying the consistent effect irrespective of any moderators. Thus, tDCS may provide a potential option to improve working memory deficits in individuals with schizophrenia. Further trials examining the cognitive benefit of tDCS with medication or other adjunctive treatments are warranted.
AB - Patients with schizophrenia experience cognitive deficits that play a central role in predicting functional outcomes. In this study, we sought to evaluate the effect of transcranial direct current stimulation (tDCS) on cognition using meta-analysis. A search was performed from inception to 8 January 2019, to identify randomized controlled trials assessing the ability of tDCS to ameliorate cognitive deficits in patients with schizophrenia and schizoaffective disorder. The effect size, calculated as the standardized mean difference (Hedge's g), was obtained with a random effect model. We analyzed mean effects on specific cognitive domains that were evaluated in four or more studies. Nine articles were included in the systematic review, which encompassed 270 patients: 133 in the active stimulation group and 137 in the sham stimulation group. Meta-analysis demonstrated a significant mean effect of tDCS on working memory (SMD = 0.49, 95% CI = 0.16 to 0.83), while non-significant results were produced for other domains. These findings were supported by sensitivity analyses indicating that the results would not change in a meaningful way after the exclusion of each single study, and meta-regression analyses verifying the consistent effect irrespective of any moderators. Thus, tDCS may provide a potential option to improve working memory deficits in individuals with schizophrenia. Further trials examining the cognitive benefit of tDCS with medication or other adjunctive treatments are warranted.
KW - Cognitive function
KW - Psychotic disorders
KW - RCTs
KW - tDCS
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UR - http://www.scopus.com/inward/citedby.url?scp=85076247296&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2019.11.011
DO - 10.1016/j.schres.2019.11.011
M3 - Article
C2 - 31822431
AN - SCOPUS:85076247296
SN - 0920-9964
VL - 216
SP - 367
EP - 373
JO - Schizophrenia Research
JF - Schizophrenia Research
ER -