Effect of optic disk drusen on nerve fiber layer thickness measured by Optical Coherence Tomography (OCT)

S. Roh; R. J. Noecker; J. S. Schuman; J. J. Weiter; T. R. Hedges; M. R. Hee; J. R. Wilkins; J. G. Coker; C. A. Puliafito; J. G. Fujimoto; E. A. Swanson; C. Mattox

Effect of optic disk drusen on nerve fiber layer thickness measured by Optical Coherence Tomography (OCT)

S. Roh, R. J. Noecker, J. S. Schuman, J. J. Weiter, T. R. Hedges, M. R. Hee, J. R. Wilkins, J. G. Coker, C. A. Puliafito, J. G. Fujimoto, E. A. Swanson, C. Mattox

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose. To evaluate the effect of optic nerve head (ONH) drusen on the nerve fiber layer (NFL) through the use of OCT. Methods. Prospective study was done on 26 eyes of 13 consecutive patients with ONH drusen and 43 eyes of 24 age-matched control subjects. Ophthalmologic examination, ONH and NFL photography. Humphrey visual fields and OCT were performed on these patients. Results. Of the 26 test eyes, 19 exhibited clinically visible ONH drusen. Seven patients had asymmetric ONH drusen, with no clinically visible ONH drusen in the contralateral eye. By OCT, the superior and inferior NFL was significantly thinner in the 19 eyes with visible ONH drusen than in the control group (p<0.001, unpaired t-Test). Increased NFL dropout was found in the eyes with visible drusen compared to the eyes that did not exhibit visible drusen (p<0.001). NFL loss was detected in the 7 eyes with no visible drusen compared to controls (p= 0.003 superiorly, p< 0.001 inferiorly). Visual fields corresponded to location of drusen and NFL thinning in 47% of eyes with visible ONH drusen (9/19), while diffuse NFL loss was detected in 58% of eyes through NFL photos (11/19). Conclusion. OCT is able to detect NFL thinning in eyes with ONH drusen, including clinically nonvisible ONH drusen. OCT appears to be a more sensitive and earlier indicator of NFL loss than visual fields or defects found through NFL photography.

Original language	English (US)
Pages (from-to)	S1096
Journal	Investigative Ophthalmology and Visual Science
Volume	37
Issue number	3
State	Published - Feb 15 1996

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Cite this

@article{81886818b3154000a773fe08d8fbb1e4,

title = "Effect of optic disk drusen on nerve fiber layer thickness measured by Optical Coherence Tomography (OCT)",

abstract = "Purpose. To evaluate the effect of optic nerve head (ONH) drusen on the nerve fiber layer (NFL) through the use of OCT. Methods. Prospective study was done on 26 eyes of 13 consecutive patients with ONH drusen and 43 eyes of 24 age-matched control subjects. Ophthalmologic examination, ONH and NFL photography. Humphrey visual fields and OCT were performed on these patients. Results. Of the 26 test eyes, 19 exhibited clinically visible ONH drusen. Seven patients had asymmetric ONH drusen, with no clinically visible ONH drusen in the contralateral eye. By OCT, the superior and inferior NFL was significantly thinner in the 19 eyes with visible ONH drusen than in the control group (p<0.001, unpaired t-Test). Increased NFL dropout was found in the eyes with visible drusen compared to the eyes that did not exhibit visible drusen (p<0.001). NFL loss was detected in the 7 eyes with no visible drusen compared to controls (p= 0.003 superiorly, p< 0.001 inferiorly). Visual fields corresponded to location of drusen and NFL thinning in 47% of eyes with visible ONH drusen (9/19), while diffuse NFL loss was detected in 58% of eyes through NFL photos (11/19). Conclusion. OCT is able to detect NFL thinning in eyes with ONH drusen, including clinically nonvisible ONH drusen. OCT appears to be a more sensitive and earlier indicator of NFL loss than visual fields or defects found through NFL photography.",

author = "S. Roh and Noecker, {R. J.} and Schuman, {J. S.} and Weiter, {J. J.} and Hedges, {T. R.} and Hee, {M. R.} and Wilkins, {J. R.} and Coker, {J. G.} and Puliafito, {C. A.} and Fujimoto, {J. G.} and Swanson, {E. A.} and C. Mattox",

note = "Funding Information: 1 Paper of the Journal Series, New Jersey Agricultural Experiment Station, Rutgers University, the State University of New Jersey, Department of Dairy Science, :New Brunswick. This work was supported in part by a grant-in-aid from the ~Tational Association of Artificial Breeders. 2Present address: Department of Physiology and Pharmacology, New York h~edical College, Flower and Fifth Avenue Hospitals, New York City.",

year = "1996",

month = feb,

day = "15",

language = "English (US)",

volume = "37",

pages = "S1096",

journal = "Investigative Ophthalmology and Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "3",

}

TY - JOUR

T1 - Effect of optic disk drusen on nerve fiber layer thickness measured by Optical Coherence Tomography (OCT)

AU - Roh, S.

AU - Noecker, R. J.

AU - Schuman, J. S.

AU - Weiter, J. J.

AU - Hedges, T. R.

AU - Hee, M. R.

AU - Wilkins, J. R.

AU - Coker, J. G.

AU - Puliafito, C. A.

AU - Fujimoto, J. G.

AU - Swanson, E. A.

AU - Mattox, C.

N1 - Funding Information: 1 Paper of the Journal Series, New Jersey Agricultural Experiment Station, Rutgers University, the State University of New Jersey, Department of Dairy Science, :New Brunswick. This work was supported in part by a grant-in-aid from the ~Tational Association of Artificial Breeders. 2Present address: Department of Physiology and Pharmacology, New York h~edical College, Flower and Fifth Avenue Hospitals, New York City.

PY - 1996/2/15

Y1 - 1996/2/15

N2 - Purpose. To evaluate the effect of optic nerve head (ONH) drusen on the nerve fiber layer (NFL) through the use of OCT. Methods. Prospective study was done on 26 eyes of 13 consecutive patients with ONH drusen and 43 eyes of 24 age-matched control subjects. Ophthalmologic examination, ONH and NFL photography. Humphrey visual fields and OCT were performed on these patients. Results. Of the 26 test eyes, 19 exhibited clinically visible ONH drusen. Seven patients had asymmetric ONH drusen, with no clinically visible ONH drusen in the contralateral eye. By OCT, the superior and inferior NFL was significantly thinner in the 19 eyes with visible ONH drusen than in the control group (p<0.001, unpaired t-Test). Increased NFL dropout was found in the eyes with visible drusen compared to the eyes that did not exhibit visible drusen (p<0.001). NFL loss was detected in the 7 eyes with no visible drusen compared to controls (p= 0.003 superiorly, p< 0.001 inferiorly). Visual fields corresponded to location of drusen and NFL thinning in 47% of eyes with visible ONH drusen (9/19), while diffuse NFL loss was detected in 58% of eyes through NFL photos (11/19). Conclusion. OCT is able to detect NFL thinning in eyes with ONH drusen, including clinically nonvisible ONH drusen. OCT appears to be a more sensitive and earlier indicator of NFL loss than visual fields or defects found through NFL photography.

AB - Purpose. To evaluate the effect of optic nerve head (ONH) drusen on the nerve fiber layer (NFL) through the use of OCT. Methods. Prospective study was done on 26 eyes of 13 consecutive patients with ONH drusen and 43 eyes of 24 age-matched control subjects. Ophthalmologic examination, ONH and NFL photography. Humphrey visual fields and OCT were performed on these patients. Results. Of the 26 test eyes, 19 exhibited clinically visible ONH drusen. Seven patients had asymmetric ONH drusen, with no clinically visible ONH drusen in the contralateral eye. By OCT, the superior and inferior NFL was significantly thinner in the 19 eyes with visible ONH drusen than in the control group (p<0.001, unpaired t-Test). Increased NFL dropout was found in the eyes with visible drusen compared to the eyes that did not exhibit visible drusen (p<0.001). NFL loss was detected in the 7 eyes with no visible drusen compared to controls (p= 0.003 superiorly, p< 0.001 inferiorly). Visual fields corresponded to location of drusen and NFL thinning in 47% of eyes with visible ONH drusen (9/19), while diffuse NFL loss was detected in 58% of eyes through NFL photos (11/19). Conclusion. OCT is able to detect NFL thinning in eyes with ONH drusen, including clinically nonvisible ONH drusen. OCT appears to be a more sensitive and earlier indicator of NFL loss than visual fields or defects found through NFL photography.

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SN - 0146-0404

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JO - Investigative Ophthalmology and Visual Science

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IS - 3

ER -

Effect of optic disk drusen on nerve fiber layer thickness measured by Optical Coherence Tomography (OCT)

Abstract

ASJC Scopus subject areas

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