Effect of reversible cross-linker, N,N′-bis(acryloyl)cystamine, on calcium ion adsorption by imprinted gels

Haruyuki Hiratani, Carmen Alvarez-Lorenzo, Jeffrey Chuang, Orhan Guney, Alexander Yu Grosberg, Toyoichi Tanaka

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Imprinted gels incorporating two different breakable cross-linkers, a PbMAA2 complex and a disulfide (S-S) bond, were prepared by radical polymerization. After the lead ions were removed by washing, these gels showed a high affinity for calcium ions. Breakage and subsequent reconnection of the S-S bonds in the absence of Ca2+ decreases the Ca2+ binding affinity of the gel. This indicates that random reconnection of the S-S bonds produces a frustration in the adsorption of Ca2+ by the carboxyl groups. However, if the S-S bonds were reconnected in the presence of Ca2+ and the Ca2+ was subsequently removed (the post-imprinting technique), the resulting gels showed a higher binding affinity for Ca2+. This indicates that the post-imprinting technique creates a more favorable conformation for Ca2+ binding in the polymer network. We interpret our data to mean that "memory" of target-binding sites was encoded effectively into the polymer network by the initial imprinting technique and then enhanced by the post-imprinting technique.

    Original languageEnglish (US)
    Pages (from-to)4431-4436
    Number of pages6
    JournalLangmuir
    Volume17
    Issue number14
    DOIs
    StatePublished - Jul 10 2001

    ASJC Scopus subject areas

    • Materials Science(all)
    • Condensed Matter Physics
    • Surfaces and Interfaces
    • Spectroscopy
    • Electrochemistry

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