Effects of 5,7-dihydroxytryptamine injections in the fornix-fimbria on locomotor activity in photocell cages and the open field

J. H. Williams, J. R. Meara, E. C. Azmitia

Research output: Contribution to journalArticle

Abstract

Microinjections of 5,7-dihydroxytryptamine (5,7-DHT) into the fornix-fimbria (FF) reduced dorsal hippocampal [3]5-HT uptake to 40% of control levels. The FF 5,7-DHT lesions increased nocturnal activity in photocell cages, but reduced central ambulation in diurnal open field tests. The lesions also disrupted both habituation of rearing across days in the open field and alternation in a Y-maze. Hence FF-derived hippocampal 5-HT terminals participate in controlling activity, but their role depends on the test apparatus and procedures.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalBehavioural Brain Research
Volume40
Issue number1
DOIs
StatePublished - Oct 30 1990

Keywords

  • 5,7-Dihydroxytryptamine
  • Alternation
  • Habituation
  • Hippocampus
  • Hyperactivity

ASJC Scopus subject areas

  • Behavioral Neuroscience

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