Effects of 5,7-dihydroxytryptamine injections in the fornix-fimbria on locomotor activity in photocell cages and the open field

J. H. Williams; J. R. Meara; E. C. Azmitia

doi:10.1016/0166-4328(90)90040-L

Effects of 5,7-dihydroxytryptamine injections in the fornix-fimbria on locomotor activity in photocell cages and the open field

J. H. Williams, J. R. Meara, E. C. Azmitia

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Microinjections of 5,7-dihydroxytryptamine (5,7-DHT) into the fornix-fimbria (FF) reduced dorsal hippocampal [³]5-HT uptake to 40% of control levels. The FF 5,7-DHT lesions increased nocturnal activity in photocell cages, but reduced central ambulation in diurnal open field tests. The lesions also disrupted both habituation of rearing across days in the open field and alternation in a Y-maze. Hence FF-derived hippocampal 5-HT terminals participate in controlling activity, but their role depends on the test apparatus and procedures.

Original language	English (US)
Pages (from-to)	37-44
Number of pages	8
Journal	Behavioural Brain Research
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/0166-4328(90)90040-L
State	Published - Oct 30 1990

Keywords

5,7-Dihydroxytryptamine
Alternation
Habituation
Hippocampus
Hyperactivity

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/0166-4328(90)90040-L

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abstract = "Microinjections of 5,7-dihydroxytryptamine (5,7-DHT) into the fornix-fimbria (FF) reduced dorsal hippocampal [3]5-HT uptake to 40% of control levels. The FF 5,7-DHT lesions increased nocturnal activity in photocell cages, but reduced central ambulation in diurnal open field tests. The lesions also disrupted both habituation of rearing across days in the open field and alternation in a Y-maze. Hence FF-derived hippocampal 5-HT terminals participate in controlling activity, but their role depends on the test apparatus and procedures.",

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AU - Meara, J. R.

AU - Azmitia, E. C.

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AB - Microinjections of 5,7-dihydroxytryptamine (5,7-DHT) into the fornix-fimbria (FF) reduced dorsal hippocampal [3]5-HT uptake to 40% of control levels. The FF 5,7-DHT lesions increased nocturnal activity in photocell cages, but reduced central ambulation in diurnal open field tests. The lesions also disrupted both habituation of rearing across days in the open field and alternation in a Y-maze. Hence FF-derived hippocampal 5-HT terminals participate in controlling activity, but their role depends on the test apparatus and procedures.

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KW - Hippocampus

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Effects of 5,7-dihydroxytryptamine injections in the fornix-fimbria on locomotor activity in photocell cages and the open field

Abstract

Keywords

ASJC Scopus subject areas

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