TY - JOUR
T1 - Effects of a behavioral intervention to reduce risk of transmission among people living with HIV
T2 - The Healthy Living Project randomized controlled study
AU - Morin, Stephen F.
AU - Chesney, Margaret A.
AU - Ehrhardt, Anke A.
AU - Kelly, Jeffrey A.
AU - Pequegnat, Willo
AU - Rotheram-Borus, Mary Jane
AU - Afifi, Abdelmonem A.
AU - Benotsch, Eric G.
AU - Brondino, Michael J.
AU - Catz, Sheryl L.
AU - Charlebois, Edwin D.
AU - Cumberland, William G.
AU - DesJarlais, Don C.
AU - Duan, Naihua
AU - Exner, Theresa M.
AU - Goldstein, Rise B.
AU - Gore-Felton, Cheryl
AU - Hirky, A. Elizabeth
AU - Johnson, Mallory O.
AU - Kertzner, Robert M.
AU - Kirshenbaum, Sheri B.
AU - Kittel, Lauren E.
AU - Klitzman, Robert
AU - Lee, Martha
AU - Levin, Bruce
AU - Lightfoot, Marguerita
AU - Pinkerton, Steven D.
AU - Remien, Robert H.
AU - Rhodes, Fen
AU - Song, Juwon
AU - Steward, Wayne T.
AU - Tross, Susan
AU - Weinhardt, Lance S.
AU - Weiss, Robert
AU - Wolfe, Hannah
AU - Wolfe, Rachel
AU - Wong, F. Lennie
AU - Batterham, Philip
AU - Comulada, W. Scott
AU - Rogers, Tyson
AU - Zhao, Yu
AU - Correale, Jackie
AU - Hackl, Kristin
AU - Hong, Daniel
AU - Huchting, Karen
AU - Mickalian, Joanne D.
AU - Peterson, Margaret
AU - Gordon, Christopher M.
AU - Rausch, Dianne
AU - Stover, Ellen
PY - 2007/2
Y1 - 2007/2
N2 - CONTEXT: The US Centers for Disease Control and Prevention (CDC) strongly recommend comprehensive risk counceling and services for people living with HIV (PLH); yet, there are no evidence-based counseling protocols. OBJECTIVE: To examine the effect of a 15-session, individually delivered, cognitive behavioral intervention on a diverse sample of PLH at risk of transmitting to others. DESIGN: This was a multisite, 2-group, randomized, controlled trial. PARTICIPANTS: Nine hundred thirty-six HIV-infected participants considered to be at risk of transmitting HIV of 3818 persons screened were randomized into the trial. Participants were recruited in Los Angeles, Milwaukee, New York, and San Francisco. INTERVENTION: Fifteen 90-minute individually delivered intervention sessions were divided into 3 modules: stress, coping, and adjustment; safer behaviors; and health behaviors. The control group received no intervention until the trial was completed. Both groups completed follow-up assessments at 5, 10, 15, 20, and 25 months after randomization. MAIN OUTCOME MEASURE: Transmission risk, as measured by the number of unprotected sexual risk acts with persons of HIV-negative or unknown status, was the main outcome measure. RESULTS: Overall, a significance difference in mean transmission risk acts was shown between the intervention and control arms over 5 to 25 months (χ = 16.0, degrees of freedom = 5; P = 0.007). The greatest reduction occurred at the 20-month follow-up, with a 36% reduction in the intervention group compared with the control group. CONCLUSION: Cognitive behavioral intervention programs can effectively reduce the potential of HIV transmission to others among PLH who report significant transmission risk behavior.
AB - CONTEXT: The US Centers for Disease Control and Prevention (CDC) strongly recommend comprehensive risk counceling and services for people living with HIV (PLH); yet, there are no evidence-based counseling protocols. OBJECTIVE: To examine the effect of a 15-session, individually delivered, cognitive behavioral intervention on a diverse sample of PLH at risk of transmitting to others. DESIGN: This was a multisite, 2-group, randomized, controlled trial. PARTICIPANTS: Nine hundred thirty-six HIV-infected participants considered to be at risk of transmitting HIV of 3818 persons screened were randomized into the trial. Participants were recruited in Los Angeles, Milwaukee, New York, and San Francisco. INTERVENTION: Fifteen 90-minute individually delivered intervention sessions were divided into 3 modules: stress, coping, and adjustment; safer behaviors; and health behaviors. The control group received no intervention until the trial was completed. Both groups completed follow-up assessments at 5, 10, 15, 20, and 25 months after randomization. MAIN OUTCOME MEASURE: Transmission risk, as measured by the number of unprotected sexual risk acts with persons of HIV-negative or unknown status, was the main outcome measure. RESULTS: Overall, a significance difference in mean transmission risk acts was shown between the intervention and control arms over 5 to 25 months (χ = 16.0, degrees of freedom = 5; P = 0.007). The greatest reduction occurred at the 20-month follow-up, with a 36% reduction in the intervention group compared with the control group. CONCLUSION: Cognitive behavioral intervention programs can effectively reduce the potential of HIV transmission to others among PLH who report significant transmission risk behavior.
KW - Behavioral trial
KW - Prevention case management
KW - Prevention with positives
UR - http://www.scopus.com/inward/record.url?scp=33847115795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847115795&partnerID=8YFLogxK
U2 - 10.1097/QAI.0b013e31802c0cae
DO - 10.1097/QAI.0b013e31802c0cae
M3 - Article
C2 - 17146375
AN - SCOPUS:33847115795
SN - 1525-4135
VL - 44
SP - 213
EP - 221
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 2
ER -