Effects of conflict and strategic processing on neural responses to errors in schizophrenia

Kayla R. Donaldson; Brian J. Roach; Judith M. Ford; Karen Lai; Kartik K. Sreenivasan; Daniel H. Mathalon

doi:10.1016/j.biopsycho.2018.11.001

Effects of conflict and strategic processing on neural responses to errors in schizophrenia

Kayla R. Donaldson, Brian J. Roach, Judith M. Ford, Karen Lai, Kartik K. Sreenivasan, Daniel H. Mathalon

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

The error-related negativity (ERN) and error-positivity (Pe) are commonly linked to error-detection and strategic processing. Studies have documented the influence of conflict probability on ERN amplitude. However, the influence of conflict probability on ERN/Pe in schizophrenia, where such components are reduced, is unknown. A modified flanker paradigm was used to examine how the probability of conflict modulates ERN and Pe amplitudes in patients with schizophrenia (n = 33) and healthy controls (n = 25). Increased ERN was observed in response to errors on low probability, incongruent trials. No such differences were observed in Pe. While ERN and Pe showed significantly reduced amplitudes in patients relative to controls, patients showed normal condition-dependent ERN and reaction-time modulation. This suggests that while the neural mechanisms generating the ERN and Pe are compromised in schizophrenia, those modulating task performance strategy and neurophysiological responses to errors based on conflict probability are intact.

Original language	English (US)
Pages (from-to)	9-18
Number of pages	10
Journal	Biological Psychology
Volume	140
DOIs	https://doi.org/10.1016/j.biopsycho.2018.11.001
State	Published - Jan 2019

Keywords

Conflict
EEG
ERN
ERP
Performance-monitoring
Schizophrenia

ASJC Scopus subject areas

General Neuroscience
Neuropsychology and Physiological Psychology

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10.1016/j.biopsycho.2018.11.001

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title = "Effects of conflict and strategic processing on neural responses to errors in schizophrenia",

abstract = "The error-related negativity (ERN) and error-positivity (Pe) are commonly linked to error-detection and strategic processing. Studies have documented the influence of conflict probability on ERN amplitude. However, the influence of conflict probability on ERN/Pe in schizophrenia, where such components are reduced, is unknown. A modified flanker paradigm was used to examine how the probability of conflict modulates ERN and Pe amplitudes in patients with schizophrenia (n = 33) and healthy controls (n = 25). Increased ERN was observed in response to errors on low probability, incongruent trials. No such differences were observed in Pe. While ERN and Pe showed significantly reduced amplitudes in patients relative to controls, patients showed normal condition-dependent ERN and reaction-time modulation. This suggests that while the neural mechanisms generating the ERN and Pe are compromised in schizophrenia, those modulating task performance strategy and neurophysiological responses to errors based on conflict probability are intact.",

keywords = "Conflict, EEG, ERN, ERP, Performance-monitoring, Schizophrenia",

author = "Donaldson, {Kayla R.} and Roach, {Brian J.} and Ford, {Judith M.} and Karen Lai and Sreenivasan, {Kartik K.} and Mathalon, {Daniel H.}",

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year = "2019",

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doi = "10.1016/j.biopsycho.2018.11.001",

language = "English (US)",

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AU - Donaldson, Kayla R.

AU - Roach, Brian J.

AU - Ford, Judith M.

AU - Lai, Karen

AU - Sreenivasan, Kartik K.

AU - Mathalon, Daniel H.

PY - 2019/1

Y1 - 2019/1

N2 - The error-related negativity (ERN) and error-positivity (Pe) are commonly linked to error-detection and strategic processing. Studies have documented the influence of conflict probability on ERN amplitude. However, the influence of conflict probability on ERN/Pe in schizophrenia, where such components are reduced, is unknown. A modified flanker paradigm was used to examine how the probability of conflict modulates ERN and Pe amplitudes in patients with schizophrenia (n = 33) and healthy controls (n = 25). Increased ERN was observed in response to errors on low probability, incongruent trials. No such differences were observed in Pe. While ERN and Pe showed significantly reduced amplitudes in patients relative to controls, patients showed normal condition-dependent ERN and reaction-time modulation. This suggests that while the neural mechanisms generating the ERN and Pe are compromised in schizophrenia, those modulating task performance strategy and neurophysiological responses to errors based on conflict probability are intact.

AB - The error-related negativity (ERN) and error-positivity (Pe) are commonly linked to error-detection and strategic processing. Studies have documented the influence of conflict probability on ERN amplitude. However, the influence of conflict probability on ERN/Pe in schizophrenia, where such components are reduced, is unknown. A modified flanker paradigm was used to examine how the probability of conflict modulates ERN and Pe amplitudes in patients with schizophrenia (n = 33) and healthy controls (n = 25). Increased ERN was observed in response to errors on low probability, incongruent trials. No such differences were observed in Pe. While ERN and Pe showed significantly reduced amplitudes in patients relative to controls, patients showed normal condition-dependent ERN and reaction-time modulation. This suggests that while the neural mechanisms generating the ERN and Pe are compromised in schizophrenia, those modulating task performance strategy and neurophysiological responses to errors based on conflict probability are intact.

KW - Conflict

KW - EEG

KW - ERN

KW - ERP

KW - Performance-monitoring

KW - Schizophrenia

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JO - Biological Psychology

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ER -

Effects of conflict and strategic processing on neural responses to errors in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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