TY - JOUR
T1 - Effects of developmental variability on the dynamics and self-organization of cell populations
AU - Prabhakara, Kaumudi H.
AU - Gholami, Azam
AU - Zykov, Vladimir S.
AU - Bodenschatz, Eberhard
N1 - Publisher Copyright:
© 2017 The Author(s). Published by IOP Publishing Ltd on behalf of Deutsche Physikalische Gesellschaft.
PY - 2017/11
Y1 - 2017/11
N2 - We report experimental and theoretical results for spatiotemporal pattern formation in cell populations, where the parameters vary in space and time due to mechanisms intrinsic to the system, namely Dictyostelium discoideum (D.d.) in the starvation phase. We find that different patterns are formed when the populations are initialized at different developmental stages, or when populations at different initial developmental stages are mixed. The experimentally observed patterns can be understood with a modified Kessler-Levine model that takes into account the initial spatial heterogeneity of the cell populations and a developmental path introduced by us, i.e. the time dependence of the various biochemical parameters. The dynamics of the parameters agree with known biochemical studies. Most importantly, the modified model reproduces not only our results, but also the observations of an independent experiment published earlier. This shows that pattern formation can be used to understand and quantify the temporal evolution of the system parameters.
AB - We report experimental and theoretical results for spatiotemporal pattern formation in cell populations, where the parameters vary in space and time due to mechanisms intrinsic to the system, namely Dictyostelium discoideum (D.d.) in the starvation phase. We find that different patterns are formed when the populations are initialized at different developmental stages, or when populations at different initial developmental stages are mixed. The experimentally observed patterns can be understood with a modified Kessler-Levine model that takes into account the initial spatial heterogeneity of the cell populations and a developmental path introduced by us, i.e. the time dependence of the various biochemical parameters. The dynamics of the parameters agree with known biochemical studies. Most importantly, the modified model reproduces not only our results, but also the observations of an independent experiment published earlier. This shows that pattern formation can be used to understand and quantify the temporal evolution of the system parameters.
KW - Dictyostelium discoideum
KW - developmental variability
KW - modified KesslerLevine model
KW - pattern formation
KW - spirals and targets
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U2 - 10.1088/1367-2630/aa9391
DO - 10.1088/1367-2630/aa9391
M3 - Article
AN - SCOPUS:85038402268
SN - 1367-2630
VL - 19
JO - New Journal of Physics
JF - New Journal of Physics
IS - 11
M1 - 113024
ER -