Effects of early unilateral blur on the macaque's visual system. I. Behavioral observations.

L. Kiorpes, R. G. Boothe, A. E. Hendrickson, J. A. Movshon, H. M. Eggers, M. S. Gizzi

Research output: Contribution to journalArticlepeer-review

Abstract

We raised 8 macaque monkeys with chronic atropinization of one eye throughout the first 6-10 months after birth. This rearing procedure produces retinal image blur, with the most pronounced contrast attenuation occurring at high spatial frequencies. Measurements of contrast sensitivity were made using behavioral methods in 6 monkeys and evoked potential methods in 2 monkeys. The results showed that this rearing procedure produced long-term deficits in the contrast sensitivity and spatial resolution of the atropinized eye, which were not due to residual losses in accommodative capacity. There was considerable interanimal variation in the magnitude of the effects on visual performance. Similar losses in visual performance are seen in some forms of human amblyopia. Rearing monkeys with chronic instillation of atropine therefore provides a nonhuman primate model for studying the underlying neural mechanisms of anisometropic amblyopia.

Original languageEnglish (US)
Pages (from-to)1318-1326
Number of pages9
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Volume7
Issue number5
DOIs
StatePublished - May 1987

ASJC Scopus subject areas

  • Neuroscience(all)

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