Effects of GABA receptor blockade on stimulation-induced feeding and self-stimulation

Linda J. Porrino, Edgar E. Coons

Research output: Contribution to journalArticlepeer-review


Frequency thresholds for eating elicited by electrical stimulation of the lateral hypothalamus of rats decreased in a dose-dependent manner after intraperitoneal (IP) administration of picrotoxin, a γ-aminobutyric acid (GABA) antagonist that blocks GABA-mediated synaptic inhibition. Strychnine IP, a glycine antagonist that blocks glycine-mediated synaptic inhibition, had no effect. By contrast, frequency thresholds for self-stimulation at the same electrode site significantly increased after picrotoxin. Again, strychnine had no effect. These findings indicate that GABAergic mechanisms are involved in both electrically-elicited feeding and self-stimulation. They also suggest a dissociation of the neural substrates which subserve these behaviors.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number1
StatePublished - Jan 1980


  • GABA
  • Hypothalamus
  • Picrotoxin
  • Self-stimulation
  • Stimulation-induced feeding

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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