Effects of gender and acute dental pain on thermal pain responses

Robert R. Edwards, Roger B. Fillingim, Shizuko Yamauchi, Asgeir Sigurdsson, Shelley Bunting, Stephen G. Mohorn, William Maixner

Research output: Contribution to journalArticlepeer-review


Objective: Considerable research suggests that females exhibit greater sensitivity to laboratory pain procedures than do males; however, whether the presence of acute clinical pain influences this sex difference in pain sensitivity has not been investigated. The present experiment investigated the effects of sex and acute dental pain on laboratory pain responses. Design: Thermal pain onset and tolerance were determined in 46 dental patients (15 male, 31 female) experiencing pain due to acute irreversible pulpitis and in 33 healthy controls (13 male, 20 female). In addition, measures of mood and coping were obtained in all participants. All subjects participated in two experimental sessions. The first session took place immediately before the patients underwent endodontic treatment for relief of pulpal pain. The second session took place approximately 1-2 weeks later, when pulpitis patients were pain free after treatment. During each session, thermal pain onset and tolerance were assessed with a 1-cm2 contact thermode applied to the right volar forearm using an ascending method of limits. Results: During both sessions, thermal pain onset and tolerance were lower in control females than in control males; however, male and female pulpitis patients did not differ in their thermal pain responses during either session. Pulpitis patients also showed greater affective distress than controls. Conclusions: These data suggest that the sex difference in thermal pain sensitivity frequently reported in pain-free subjects appears to be absent in patients presenting with acute dental pain. However, this effect cannot be explained solely based on the presence of clinical pain because the effect on pain threshold and tolerance persisted into session 2, when pulpitis patients were pain free. Potential explanations for these results are discussed.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalClinical Journal of Pain
Issue number3
StatePublished - Sep 1999


  • Dental pain
  • Gender
  • Pain threshold
  • Pain tolerance
  • Sex

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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