Effects of GH/IGF on the Aging Mitochondria

Sher Bahadur Poudel, Manisha Dixit, Maria Neginskaya, Karthik Nagaraj, Evgeny Pavlov, Haim Werner, Shoshana Yakar

Research output: Contribution to journalReview articlepeer-review


The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significant roles in cell differentiation, function, and survival. In mammals, these hormones peak during puberty and decline gradually during adulthood and aging. Here, we review the evidence that GH and IGF-1 regulate mitochondrial mass and function and contribute to specific processes of cellular aging. Specifically, we discuss the contribution of GH and IGF-1 to mitochondrial biogenesis, respiration and ATP production, oxidative stress, senescence, and apoptosis. Particular emphasis was placed on how these pathways intersect during aging.

Original languageEnglish (US)
Article number875
Issue number6
StatePublished - Jun 2 2020


  • aging
  • growth hormone
  • insulin-like growth factor-1
  • mitochondria
  • oxidative stress
  • senescence

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'Effects of GH/IGF on the Aging Mitochondria'. Together they form a unique fingerprint.

Cite this