Effects of GH/IGF on the Aging Mitochondria

Sher Bahadur Poudel, Manisha Dixit, Maria Neginskaya, Karthik Nagaraj, Evgeny Pavlov, Haim Werner, Shoshana Yakar

Research output: Contribution to journalReview article

Abstract

The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significant roles in cell differentiation, function, and survival. In mammals, these hormones peak during puberty and decline gradually during adulthood and aging. Here, we review the evidence that GH and IGF-1 regulate mitochondrial mass and function and contribute to specific processes of cellular aging. Specifically, we discuss the contribution of GH and IGF-1 to mitochondrial biogenesis, respiration and ATP production, oxidative stress, senescence, and apoptosis. Particular emphasis was placed on how these pathways intersect during aging.

Original languageEnglish (US)
JournalCells
Volume9
Issue number6
DOIs
StatePublished - Jun 2 2020

Keywords

  • aging
  • growth hormone
  • insulin-like growth factor-1
  • mitochondria
  • oxidative stress
  • senescence

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  • Cite this

    Poudel, S. B., Dixit, M., Neginskaya, M., Nagaraj, K., Pavlov, E., Werner, H., & Yakar, S. (2020). Effects of GH/IGF on the Aging Mitochondria. Cells, 9(6). https://doi.org/10.3390/cells9061384