Effects of GH/IGF on the Aging Mitochondria

Sher Bahadur Poudel; Manisha Dixit; Maria Neginskaya; Karthik Nagaraj; Evgeny Pavlov; Haim Werner; Shoshana Yakar

doi:10.3390/cells9061384

Effects of GH/IGF on the Aging Mitochondria

Sher Bahadur Poudel, Manisha Dixit, Maria Neginskaya, Karthik Nagaraj, Evgeny Pavlov, Haim Werner, Shoshana Yakar

Molecular Pathobiology

Research output: Contribution to journal › Review article › peer-review

Abstract

The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significant roles in cell differentiation, function, and survival. In mammals, these hormones peak during puberty and decline gradually during adulthood and aging. Here, we review the evidence that GH and IGF-1 regulate mitochondrial mass and function and contribute to specific processes of cellular aging. Specifically, we discuss the contribution of GH and IGF-1 to mitochondrial biogenesis, respiration and ATP production, oxidative stress, senescence, and apoptosis. Particular emphasis was placed on how these pathways intersect during aging.

Original language	English (US)
Article number	875
Journal	Cells
Volume	9
Issue number	6
DOIs	https://doi.org/10.3390/cells9061384
State	Published - Jun 2 2020

Keywords

aging
growth hormone
insulin-like growth factor-1
mitochondria
oxidative stress
senescence

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells9061384

Cite this

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title = "Effects of GH/IGF on the Aging Mitochondria",

abstract = "The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significant roles in cell differentiation, function, and survival. In mammals, these hormones peak during puberty and decline gradually during adulthood and aging. Here, we review the evidence that GH and IGF-1 regulate mitochondrial mass and function and contribute to specific processes of cellular aging. Specifically, we discuss the contribution of GH and IGF-1 to mitochondrial biogenesis, respiration and ATP production, oxidative stress, senescence, and apoptosis. Particular emphasis was placed on how these pathways intersect during aging.",

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T1 - Effects of GH/IGF on the Aging Mitochondria

AU - Poudel, Sher Bahadur

AU - Dixit, Manisha

AU - Neginskaya, Maria

AU - Nagaraj, Karthik

AU - Pavlov, Evgeny

AU - Werner, Haim

AU - Yakar, Shoshana

PY - 2020/6/2

Y1 - 2020/6/2

N2 - The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significant roles in cell differentiation, function, and survival. In mammals, these hormones peak during puberty and decline gradually during adulthood and aging. Here, we review the evidence that GH and IGF-1 regulate mitochondrial mass and function and contribute to specific processes of cellular aging. Specifically, we discuss the contribution of GH and IGF-1 to mitochondrial biogenesis, respiration and ATP production, oxidative stress, senescence, and apoptosis. Particular emphasis was placed on how these pathways intersect during aging.

AB - The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significant roles in cell differentiation, function, and survival. In mammals, these hormones peak during puberty and decline gradually during adulthood and aging. Here, we review the evidence that GH and IGF-1 regulate mitochondrial mass and function and contribute to specific processes of cellular aging. Specifically, we discuss the contribution of GH and IGF-1 to mitochondrial biogenesis, respiration and ATP production, oxidative stress, senescence, and apoptosis. Particular emphasis was placed on how these pathways intersect during aging.

KW - aging

KW - growth hormone

KW - insulin-like growth factor-1

KW - mitochondria

KW - oxidative stress

KW - senescence

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Effects of GH/IGF on the Aging Mitochondria

Abstract

Keywords

ASJC Scopus subject areas

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