Effects of healthy aging measured by intracranial compartment volumes using a designed MR brain database

Bénédicte Mortamet, Donglin Zeng, Guido Gerig, Marcel Prastawa, Elizabeth Bullitt

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    A publicly available database of high-quality, multi-modal MR brain images of carefully screened healthy subjects, equally divided by sex, and with an equal number of subjects per age decade, would be of high value to investigators interested in the statistical study of disease. This report describes initial use of an accumulating healthy database currently comprising 50 subjects aged 20-72. We examine changes by age and sex to the volumes of gray matter, white matter and cerebrospinal fluid for subjects within the database. We conclude that traditional views of healthy aging should be revised. Significant atrophy does not appear in healthy subjects 60 or 70 years old. Gray matter loss is not restricted to senility, but begins in early adulthood and is progressive. The percentage of white matter increases with age. A carefully-designed healthy database should be useful in the statistical analysis of many age- and non-age-related diseases.

    Original languageEnglish (US)
    Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - 8th International Conference, Proceedings
    PublisherSpringer Verlag
    Pages383-391
    Number of pages9
    ISBN (Print)3540293272, 9783540293279
    DOIs
    StatePublished - 2005
    Event8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - Palm Springs, CA, United States
    Duration: Oct 26 2005Oct 29 2005

    Publication series

    NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume3749 LNCS
    ISSN (Print)0302-9743
    ISSN (Electronic)1611-3349

    Other

    Other8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005
    CountryUnited States
    CityPalm Springs, CA
    Period10/26/0510/29/05

    ASJC Scopus subject areas

    • Theoretical Computer Science
    • Computer Science(all)

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