Effects of increasing osmolality on rat ileal smooth muscle

Joel D. Schiff, Norbert I.A. Overweg

Research output: Contribution to journalArticlepeer-review


The effects of changing bathing medium osmolality on tension generation in smooth muscle were studied on potassium-depolarized segments of rat ileum. Increasing the tonicity of the medium evokes a transient relaxation of the smooth muscle; restoration of isotonicity evokes a transient contraction of similar amplitude and time course. While immersed in hypertonic media of less than 1.3 times normal tonicity, the smooth muscle slowly increases its isometric tension; in media of nearly twice normal tonicity, the smooth muscle loses tension. All of these effects occur whether the medium is made hypertonic with added NaCl or sucrose.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalPflügers Archiv European Journal of Physiology
Issue number1
StatePublished - Dec 1980


  • Hypertonicity
  • Ileum
  • Osmolality
  • Smooth muscle

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)


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