Effects of increasing osmolality on rat ileal smooth muscle

Joel D. Schiff; Norbert I.A. Overweg

doi:10.1007/BF00587931

Effects of increasing osmolality on rat ileal smooth muscle

Joel D. Schiff, Norbert I.A. Overweg

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of changing bathing medium osmolality on tension generation in smooth muscle were studied on potassium-depolarized segments of rat ileum. Increasing the tonicity of the medium evokes a transient relaxation of the smooth muscle; restoration of isotonicity evokes a transient contraction of similar amplitude and time course. While immersed in hypertonic media of less than 1.3 times normal tonicity, the smooth muscle slowly increases its isometric tension; in media of nearly twice normal tonicity, the smooth muscle loses tension. All of these effects occur whether the medium is made hypertonic with added NaCl or sucrose.

Original language	English (US)
Pages (from-to)	75-79
Number of pages	5
Journal	Pflügers Archiv European Journal of Physiology
Volume	389
Issue number	1
DOIs	https://doi.org/10.1007/BF00587931
State	Published - Dec 1980

Keywords

Hypertonicity
Ileum
Osmolality
Smooth muscle

ASJC Scopus subject areas

Physiology
Clinical Biochemistry
Physiology (medical)

Access to Document

10.1007/BF00587931

Cite this

@article{6412d8b24fa741758f37968f25d20168,

title = "Effects of increasing osmolality on rat ileal smooth muscle",

abstract = "The effects of changing bathing medium osmolality on tension generation in smooth muscle were studied on potassium-depolarized segments of rat ileum. Increasing the tonicity of the medium evokes a transient relaxation of the smooth muscle; restoration of isotonicity evokes a transient contraction of similar amplitude and time course. While immersed in hypertonic media of less than 1.3 times normal tonicity, the smooth muscle slowly increases its isometric tension; in media of nearly twice normal tonicity, the smooth muscle loses tension. All of these effects occur whether the medium is made hypertonic with added NaCl or sucrose.",

keywords = "Hypertonicity, Ileum, Osmolality, Smooth muscle",

author = "Schiff, {Joel D.} and Overweg, {Norbert I.A.}",

year = "1980",

month = dec,

doi = "10.1007/BF00587931",

language = "English (US)",

volume = "389",

pages = "75--79",

journal = "Pfl{\"u}gers Archiv European Journal of Physiology",

issn = "0031-6768",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

TY - JOUR

T1 - Effects of increasing osmolality on rat ileal smooth muscle

AU - Schiff, Joel D.

AU - Overweg, Norbert I.A.

PY - 1980/12

Y1 - 1980/12

N2 - The effects of changing bathing medium osmolality on tension generation in smooth muscle were studied on potassium-depolarized segments of rat ileum. Increasing the tonicity of the medium evokes a transient relaxation of the smooth muscle; restoration of isotonicity evokes a transient contraction of similar amplitude and time course. While immersed in hypertonic media of less than 1.3 times normal tonicity, the smooth muscle slowly increases its isometric tension; in media of nearly twice normal tonicity, the smooth muscle loses tension. All of these effects occur whether the medium is made hypertonic with added NaCl or sucrose.

AB - The effects of changing bathing medium osmolality on tension generation in smooth muscle were studied on potassium-depolarized segments of rat ileum. Increasing the tonicity of the medium evokes a transient relaxation of the smooth muscle; restoration of isotonicity evokes a transient contraction of similar amplitude and time course. While immersed in hypertonic media of less than 1.3 times normal tonicity, the smooth muscle slowly increases its isometric tension; in media of nearly twice normal tonicity, the smooth muscle loses tension. All of these effects occur whether the medium is made hypertonic with added NaCl or sucrose.

KW - Hypertonicity

KW - Ileum

KW - Osmolality

KW - Smooth muscle

UR - http://www.scopus.com/inward/record.url?scp=0019194039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019194039&partnerID=8YFLogxK

U2 - 10.1007/BF00587931

DO - 10.1007/BF00587931

M3 - Article

C2 - 7193468

AN - SCOPUS:0019194039

SN - 0031-6768

VL - 389

SP - 75

EP - 79

JO - Pflügers Archiv European Journal of Physiology

JF - Pflügers Archiv European Journal of Physiology

IS - 1

ER -

Effects of increasing osmolality on rat ileal smooth muscle

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this