Effects of microinjections of 5,7-dihydroxytryptamine in the suprachiasmatic nuclei of the rat on serotonin reuptake and the circadian variation of corticosterone levels

Jonathan H. Williams, Vivienne M. Miall-Allen, Margaret Klinowski, Efrain C. Azmitia

Research output: Contribution to journalArticlepeer-review

Abstract

The role of the 5-hydroxytryptamine (5-HT) terminals in the suprachiasmatic nucleus (SCN) in the production of the circadian variation of corticosterone secretion was investigated by lesioning the 5-HT inputs to the SCN with 5,7-dihydroxytryptamine (5,7-DHT). Vehicle-injected animals showed a normal circadian variation of corticosterone levels. In contrast, the mean corticosterone levels of the 5,7-DHT-lesioned group were intermediate between control peak and trough values, and although the individual rats showed fluctuations, no significant circadian variation was present in the group as a whole.3H-5-HT reuptake in the SCN was reduced to 38% of the mean control level in the 5,7-DHT-lesioned group, but ventromedial hypothalamic3H-5-HT reuptake was only decreased to 82% of control. These results indicated that the SCN 5-HT terminals may play an important role in the synchronization of the circadian variation of corticosterone secretion.

Original languageEnglish (US)
Pages (from-to)431-435
Number of pages5
JournalNeuroendocrinology
Volume36
Issue number6
DOIs
StatePublished - 1983

Keywords

  • 5
  • 7-Dihydroxytryptamine
  • Circadian rhythm
  • Corticosterone
  • Serotonin
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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