Effects of neonatal C-fiber depletion on the integration of paired-whisker inputs in rat barrel cortex

R. Farazifard, R. Kiani, M. Noorbakhsh, H. Esteky

Research output: Contribution to journalArticle

Abstract

In the present study we used computer-controlled mechanical displacement of paired whiskers in normal and C-fiber-depleted rats to quantitatively examine the role of C-fibers in the receptive field properties of barrel cortical cells. In rodents when adjacent whiskers are stimulated prior to the main whisker responses to the main whisker are inhibited, the degree of inhibition being a function of the inter-deflection intervals. The adjacent-whisker-evoked inhibition of barrel cells in normal and C-fiber-depleted rats using neonatal capsaicin treatment were examined by stimulation of the adjacent whisker zero, 10, 20, 30, 50 and 100 ms prior to the main whisker deflection. C-fiber depletion reduced the suppressive effect of paired whisker stimulation at all of the tested inter-stimulus intervals without changing response latencies. The main effect was observed during the later phase of response (about 13-17 ms from stimulus onset) and not during the initial responses (7-12 ms). These results suggest that the inhibitory receptive field properties of low-threshold mechanical somatosensory cells are influenced by C-fibers.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalExperimental Brain Research
Volume162
Issue number1
DOIs
StatePublished - Mar 2005

Keywords

  • Barrel cortex
  • Capsaicin
  • Object recognition
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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