TY - JOUR
T1 - Effects of phenylpropanolamine on gastric retention in the adult rat
AU - Wellman, P. J.
AU - Arasteh, K.
AU - Ruddle, J. L.
AU - Strickland, M. D.
N1 - Funding Information:
was supported by a grant from the Thompson Medical
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1986/7
Y1 - 1986/7
N2 - Phenylpropanolamine (PPA) induces anorexia and weight loss via an as yet unidentified mechanism. In the present study, we evaluated the inhibitory action of PPA on gastric emptying. Adult female Sprague-Dawley rats consumed a wet-mash test meal and were then treated (IP) with either saline or 5, 10, 20 or 40 mg/kg PPA. Gastric retention (ratio of weight of gastric content to weight of mash consumed) was evaluated immediately after the meal in a group of saline-treated rats or 3 hours after the meal in the drug groups and another saline-treated group. Rats treated with saline exhibited minimal retention (0.21) over a 3 hour period whereas rats treated with 5, 10, 20 or 40 mg/kg dl-PPA exhibited increased gastric retention ratios of 0.29, 0.66, 0.63 and 1.38, respectively. These data demonstrate that PPA has a marked inhibitory action on gastric emptying and suggest that further studies are warranted to evaluate the possible contribution of gastric retention to the anorexic action of PPA.
AB - Phenylpropanolamine (PPA) induces anorexia and weight loss via an as yet unidentified mechanism. In the present study, we evaluated the inhibitory action of PPA on gastric emptying. Adult female Sprague-Dawley rats consumed a wet-mash test meal and were then treated (IP) with either saline or 5, 10, 20 or 40 mg/kg PPA. Gastric retention (ratio of weight of gastric content to weight of mash consumed) was evaluated immediately after the meal in a group of saline-treated rats or 3 hours after the meal in the drug groups and another saline-treated group. Rats treated with saline exhibited minimal retention (0.21) over a 3 hour period whereas rats treated with 5, 10, 20 or 40 mg/kg dl-PPA exhibited increased gastric retention ratios of 0.29, 0.66, 0.63 and 1.38, respectively. These data demonstrate that PPA has a marked inhibitory action on gastric emptying and suggest that further studies are warranted to evaluate the possible contribution of gastric retention to the anorexic action of PPA.
KW - Anorexia Phenylpropanolamine Gastric retention
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U2 - 10.1016/0361-9230(86)90169-3
DO - 10.1016/0361-9230(86)90169-3
M3 - Article
C2 - 3756541
AN - SCOPUS:0022519351
SN - 0361-9230
VL - 17
SP - 127
EP - 128
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 1
ER -