Effects of prenatal 5-methoxytryptamine and parachlorophenylalanine on serotonergic uptake and behavior in the neonatal rat

A. Shemer, P. M. Whitaker-Azmitia, E. C. Azmitia

Research output: Contribution to journalArticlepeer-review

Abstract

Parachlorophenylalanine (pCPA) or 5-methoxytryptamine (5MT) was administered to pregnant Sprague Dawley rats from day 8 (D8) of gestation till D17 and from D12 until birth respectively. Birth weights of both drug groups of neonates were approximately 20% less than the saline-injected controls. 5MT neonates showed a significant reduction of high affinity 3H-5HT uptake in the brainstem at all three time points: D1, D15, D30, and a slight reduction in the forebrain reaching significance only on D30. The pCPA animals showed a significant reduction in the brainstem and forebrain on D1 and D30, but only a small nonsignificant reduction in both areas on D15. Behaviors measured on day 15 revealed that in general activity, spontaneous alternaton, and passive avoidance both drug groups of neonates showed deficits: less activity, less alternation and less avoidance.

Original languageEnglish (US)
Pages (from-to)847-851
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume30
Issue number4
DOIs
StatePublished - Aug 1988

Keywords

  • 5-Methoxytryptamine
  • Behavior
  • Parachlorophenylalanine Development
  • Prenatal
  • Serotonin
  • Uptake

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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