Effects of prenatal 5-methoxytryptamine and parachlorophenylalanine on serotonergic uptake and behavior in the neonatal rat

Parachlorophenylalanine (pCPA) or 5-methoxytryptamine (5MT) was administered to pregnant Sprague Dawley rats from day 8 (D8) of gestation till D17 and from D12 until birth respectively. Birth weights of both drug groups of neonates were approximately 20% less than the saline-injected controls. 5MT neonates showed a significant reduction of high affinity ³H-5HT uptake in the brainstem at all three time points: D1, D15, D30, and a slight reduction in the forebrain reaching significance only on D30. The pCPA animals showed a significant reduction in the brainstem and forebrain on D1 and D30, but only a small nonsignificant reduction in both areas on D15. Behaviors measured on day 15 revealed that in general activity, spontaneous alternaton, and passive avoidance both drug groups of neonates showed deficits: less activity, less alternation and less avoidance.