Effects of regulatory BC1 RNA deletion on synaptic plasticity, learning, and memory

Ain Chung, Nessy Dahan, Juan Marcos Alarcon, André A. Fenton

Research output: Contribution to journalArticlepeer-review

Abstract

Nonprotein coding dendritic BC1 RNA regulates translation of mRNAs in neurons. We examined two lines of BC1 knockout mice and report that loss of BC1 RNA exaggerates group I mGluR-stimulated LTD of the Schaffer collateral synapse, with one of the lines showing a much more enhanced DHPG-induced LTD than the other. When the animals were given the hippocampus- synaptic plasticity-dependent active place avoidance task, learning and memory were impaired in the BC1-KO line with the more severely altered DHPG-induced LTD. These findings indicate a role for BC1 RNA control of mGluR-dependent synaptic function in hippocampus and associated cognitive ability.

Original languageEnglish (US)
Pages (from-to)646-649
Number of pages4
JournalLearning and Memory
Volume24
Issue number12
DOIs
StatePublished - Dec 2017

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'Effects of regulatory BC1 RNA deletion on synaptic plasticity, learning, and memory'. Together they form a unique fingerprint.

Cite this