Effects of regulatory BC1 RNA deletion on synaptic plasticity, learning, and memory

Ain Chung, Nessy Dahan, Juan Marcos Alarcon, André A. Fenton

Research output: Contribution to journalArticle

Abstract

Nonprotein coding dendritic BC1 RNA regulates translation of mRNAs in neurons. We examined two lines of BC1 knockout mice and report that loss of BC1 RNA exaggerates group I mGluR-stimulated LTD of the Schaffer collateral synapse, with one of the lines showing a much more enhanced DHPG-induced LTD than the other. When the animals were given the hippocampus- synaptic plasticity-dependent active place avoidance task, learning and memory were impaired in the BC1-KO line with the more severely altered DHPG-induced LTD. These findings indicate a role for BC1 RNA control of mGluR-dependent synaptic function in hippocampus and associated cognitive ability.

Original languageEnglish (US)
Pages (from-to)646-649
Number of pages4
JournalLearning and Memory
Volume24
Issue number12
DOIs
StatePublished - Dec 2017

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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