Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects

Lidia Glodzik; Henry Rusinek; Angela Kamer; Elizabeth Pirraglia; Wai Tsui; Lisa Mosconi; Yi Li; Pauline McHugh; John Murray; Schantel Williams; Ricardo S. Osorio; Catherine Randall; Tracy Butler; Anup Deshpande; Shankar Vallabhajolusa; Mony de Leon

doi:10.1016/j.dadm.2016.02.007

Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects

Lidia Glodzik, Henry Rusinek, Angela Kamer, Elizabeth Pirraglia, Wai Tsui, Lisa Mosconi, Yi Li, Pauline McHugh, John Murray, Schantel Williams, Ricardo S. Osorio, Catherine Randall, Tracy Butler, Anup Deshpande, Shankar Vallabhajolusa, Mony de Leon

Periodontology and Implant Dentistry

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Hypertension, hypercholesterolemia, and obesity increase the risk of dementia. Although their detection is commonly followed by an introduction of treatment, little is known about how medications frequently used to treat vascular risk affect amyloid deposition. Methods: A cross-sectional study of 156 subjects who underwent positron emission tomography with PiB. Using linear regression, we tested whether blood pressure, cholesterol, overweight/obese status, angiotensin receptor blockers (ARBs), beta-blockers, diuretics, angiotensin converting enzyme inhibitors, and statins predicted amyloid deposition. Results: The use of ARBs (β = -.15, P = .044) and diuretics (β = -.20, P = .006) predicted less amyloid accumulation; older age (β = .29, P < .001) and statins (β = .23, P = .004) were related to greater amyloid deposition. Overweight and/or obese women had more cortical amyloid than their peers. Discussion: Prospective studies should confirm effects of drugs and increased body weight on amyloid accumulation and establish whether they translate into measurable clinical outcomes. Women may be more susceptible to harmful effects of obesity.

Original language	English (US)
Pages (from-to)	95-104
Number of pages	10
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	2
DOIs	https://doi.org/10.1016/j.dadm.2016.02.007
State	Published - 2016

Keywords

Amyloid
Antihypertensive medications
Brain
Diuretics
Healthy elderly
PET-PiB
Statins angiotensin receptor blockers
Vascular risk factors

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1016/j.dadm.2016.02.007

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Glodzik, L., Rusinek, H., Kamer, A., Pirraglia, E., Tsui, W., Mosconi, L., Li, Y., McHugh, P., Murray, J., Williams, S., Osorio, R. S., Randall, C., Butler, T., Deshpande, A., Vallabhajolusa, S., & de Leon, M. (2016). Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 2, 95-104. https://doi.org/10.1016/j.dadm.2016.02.007

Glodzik, L, Rusinek, H, Kamer, A, Pirraglia, E, Tsui, W, Mosconi, L, Li, Y, McHugh, P, Murray, J, Williams, S, Osorio, RS, Randall, C, Butler, T, Deshpande, A, Vallabhajolusa, S & de Leon, M 2016, 'Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 2, pp. 95-104. https://doi.org/10.1016/j.dadm.2016.02.007

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abstract = "Introduction: Hypertension, hypercholesterolemia, and obesity increase the risk of dementia. Although their detection is commonly followed by an introduction of treatment, little is known about how medications frequently used to treat vascular risk affect amyloid deposition. Methods: A cross-sectional study of 156 subjects who underwent positron emission tomography with PiB. Using linear regression, we tested whether blood pressure, cholesterol, overweight/obese status, angiotensin receptor blockers (ARBs), beta-blockers, diuretics, angiotensin converting enzyme inhibitors, and statins predicted amyloid deposition. Results: The use of ARBs (β = -.15, P = .044) and diuretics (β = -.20, P = .006) predicted less amyloid accumulation; older age (β = .29, P < .001) and statins (β = .23, P = .004) were related to greater amyloid deposition. Overweight and/or obese women had more cortical amyloid than their peers. Discussion: Prospective studies should confirm effects of drugs and increased body weight on amyloid accumulation and establish whether they translate into measurable clinical outcomes. Women may be more susceptible to harmful effects of obesity.",

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author = "Lidia Glodzik and Henry Rusinek and Angela Kamer and Elizabeth Pirraglia and Wai Tsui and Lisa Mosconi and Yi Li and Pauline McHugh and John Murray and Schantel Williams and Osorio, {Ricardo S.} and Catherine Randall and Tracy Butler and Anup Deshpande and Shankar Vallabhajolusa and {de Leon}, Mony",

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year = "2016",

doi = "10.1016/j.dadm.2016.02.007",

language = "English (US)",

volume = "2",

pages = "95--104",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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T1 - Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects

AU - Glodzik, Lidia

AU - Rusinek, Henry

AU - Kamer, Angela

AU - Pirraglia, Elizabeth

AU - Tsui, Wai

AU - Mosconi, Lisa

AU - Li, Yi

AU - McHugh, Pauline

AU - Murray, John

AU - Williams, Schantel

AU - Osorio, Ricardo S.

AU - Randall, Catherine

AU - Butler, Tracy

AU - Deshpande, Anup

AU - Vallabhajolusa, Shankar

AU - de Leon, Mony

PY - 2016

Y1 - 2016

N2 - Introduction: Hypertension, hypercholesterolemia, and obesity increase the risk of dementia. Although their detection is commonly followed by an introduction of treatment, little is known about how medications frequently used to treat vascular risk affect amyloid deposition. Methods: A cross-sectional study of 156 subjects who underwent positron emission tomography with PiB. Using linear regression, we tested whether blood pressure, cholesterol, overweight/obese status, angiotensin receptor blockers (ARBs), beta-blockers, diuretics, angiotensin converting enzyme inhibitors, and statins predicted amyloid deposition. Results: The use of ARBs (β = -.15, P = .044) and diuretics (β = -.20, P = .006) predicted less amyloid accumulation; older age (β = .29, P < .001) and statins (β = .23, P = .004) were related to greater amyloid deposition. Overweight and/or obese women had more cortical amyloid than their peers. Discussion: Prospective studies should confirm effects of drugs and increased body weight on amyloid accumulation and establish whether they translate into measurable clinical outcomes. Women may be more susceptible to harmful effects of obesity.

AB - Introduction: Hypertension, hypercholesterolemia, and obesity increase the risk of dementia. Although their detection is commonly followed by an introduction of treatment, little is known about how medications frequently used to treat vascular risk affect amyloid deposition. Methods: A cross-sectional study of 156 subjects who underwent positron emission tomography with PiB. Using linear regression, we tested whether blood pressure, cholesterol, overweight/obese status, angiotensin receptor blockers (ARBs), beta-blockers, diuretics, angiotensin converting enzyme inhibitors, and statins predicted amyloid deposition. Results: The use of ARBs (β = -.15, P = .044) and diuretics (β = -.20, P = .006) predicted less amyloid accumulation; older age (β = .29, P < .001) and statins (β = .23, P = .004) were related to greater amyloid deposition. Overweight and/or obese women had more cortical amyloid than their peers. Discussion: Prospective studies should confirm effects of drugs and increased body weight on amyloid accumulation and establish whether they translate into measurable clinical outcomes. Women may be more susceptible to harmful effects of obesity.

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KW - Antihypertensive medications

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KW - Diuretics

KW - Healthy elderly

KW - PET-PiB

KW - Statins angiotensin receptor blockers

KW - Vascular risk factors

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JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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ER -

Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects

Abstract

Keywords

ASJC Scopus subject areas

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