Efficacy of sub-antimicrobial dose doxycycline in post-menopausal women: Clinical outcomes

Richard A. Reinhardt, Julie A. Stoner, Lorne M. Golub, Mark S. Wolff, His Ming Lee, Trudy A. Meinberg, James C. Lynch, Maria E. Ryan, Timo Sorsa, Jeffrey B. Payne

Research output: Contribution to journalArticlepeer-review


Aims: To determine the clinical efficacy of a 2-year continuous sub-antimicrobial dose doxycycline (SDD; 20 mg bid) in post-menopausal, osteopenic, oestrogen-deficient women on periodontal maintenance. Materials and Methods: One-hundred and twenty-eight subjects were randomized to SDD (n=64) or placebo (n=64). Clinical measurements were performed at posterior interproximal sites at baseline and every 6 months during this 2-year randomized, double-blind, placebo-controlled clinical trial with adjunctive, no-cost 3-4-month periodontal maintenance. Statistical analyses of secondary outcomes from this clinical trial used Generalized Estimating Equations in primarily intent-to-treat analyses. Results: For the placebo group, 3.4% of the sites showed improvement in clinical attachment levels (CAL) and 2.7% had progressive loss in CAL; for the SDD group, 5.0% of the sites showed an improvement in CAL and 2.2% had progressive loss in CAL. This difference (2.1% of sites) was more favourable in the SDD group than in the placebo [odds ratio (OR)=0.81%, 95% confidence interval (CI): 0.67-0.97, p=0.03] in these well-maintained patients, whereas probing depths, bleeding on probing and supragingival plaque did not differ significantly between groups (p>0.2). However, in exploratory subgroup analysis of non-smokers, SDD showed reduced bleeding versus placebo (27% versus 33%; p=0.05). In protocol-adherent subjects, the odds of bleeding were 34% lower for SDD (p=0.05). Conclusions: Analyses of secondary outcomes of this clinical trial indicated that SDD may be of benefit in reducing progressive attachment loss in post-menopausal females; additional research is needed to confirm these findings. Protocol registered at ClinicalTrials.gov. Identifier:NCT00066027

Original languageEnglish (US)
Pages (from-to)768-775
Number of pages8
JournalJournal of clinical periodontology
Issue number9
StatePublished - Sep 2007


  • Osteopenia
  • Periodontal maintenance
  • Periodontitis
  • Post-menopausal
  • Randomized clinical trial
  • Relative clinical attachment
  • Sub-antimicrobial dose doxycycline

ASJC Scopus subject areas

  • Periodontics


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