Electroceuticals in the Gastrointestinal Tract

Khalil B. Ramadi, Shriya S. Srinivasan, Giovanni Traverso

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    The field of electroceuticals has attracted considerable attention over the past few decades as a novel therapeutic modality. The gastrointestinal (GI) tract (GIT) holds significant potential as a target for electroceuticals as the intersection of neural, endocrine, and immune systems. We review recent developments in electrical stimulation of various portions of the GIT (including esophagus, stomach, and small and large intestine) and nerves projecting to the GIT and supportive organs. This has been tested with varying degrees of success for several dysmotility, inflammatory, hormonal, and neurologic disorders. We outline a vision for the future of GI electroceuticals, building on advances in mechanistic understanding of GI physiology coupled with novel ingestible technologies. The next wave of electroceutical therapies will be minimally invasive and more targeted than current approaches, making them an indispensable tool in the clinical armamentarium.

    Original languageEnglish (US)
    Pages (from-to)960-976
    Number of pages17
    JournalTrends in Pharmacological Sciences
    Volume41
    Issue number12
    DOIs
    StatePublished - Dec 2020

    Keywords

    • electrical stimulation
    • electroceuticals
    • gastrointestinal tract

    ASJC Scopus subject areas

    • Toxicology
    • Pharmacology

    Fingerprint Dive into the research topics of 'Electroceuticals in the Gastrointestinal Tract'. Together they form a unique fingerprint.

    Cite this