Electrodeformation of White Blood Cells Enriched with Gold Nanoparticles

Nicholas G. Hallfors; Jeremy C.M. Teo; Peter M. Bertone; Chakra P. Joshi; Ajymurat Orozaliev; Matthew N. Martin; A. F. Isakovic

doi:10.3390/pr10010134

Electrodeformation of White Blood Cells Enriched with Gold Nanoparticles

Nicholas G. Hallfors, Jeremy C.M. Teo, Peter M. Bertone, Chakra P. Joshi, Ajymurat Orozaliev, Matthew N. Martin, A. F. Isakovic

Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

The elasticity of white blood cells (WBCs) provides valuable insight into the condition of the cells themselves, the presence of some diseases, as well as immune system activity. In this work, we describe a novel process of refined control of WBCs’ elasticity through a combined use of gold nanoparticles (AuNPs) and the microelectrode array device. The capture and controlled deformation of gold nanoparticles enriched white blood cells in vitro are demonstrated and quantified. Gold nanoparticles enhance the effect of electrically induced deformation and make the DEP-related processes more controllable.

Original language	English (US)
Article number	134
Journal	Processes
Volume	10
Issue number	1
DOIs	https://doi.org/10.3390/pr10010134
State	Published - Jan 2022

Keywords

Electrodeformation
Lab-on-chip
Leukocytes
Nanoparticles
Young’s modulus

ASJC Scopus subject areas

Bioengineering
Chemical Engineering (miscellaneous)
Process Chemistry and Technology

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10.3390/pr10010134

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title = "Electrodeformation of White Blood Cells Enriched with Gold Nanoparticles",

abstract = "The elasticity of white blood cells (WBCs) provides valuable insight into the condition of the cells themselves, the presence of some diseases, as well as immune system activity. In this work, we describe a novel process of refined control of WBCs{\textquoteright} elasticity through a combined use of gold nanoparticles (AuNPs) and the microelectrode array device. The capture and controlled deformation of gold nanoparticles enriched white blood cells in vitro are demonstrated and quantified. Gold nanoparticles enhance the effect of electrically induced deformation and make the DEP-related processes more controllable.",

keywords = "Electrodeformation, Lab-on-chip, Leukocytes, Nanoparticles, Young{\textquoteright}s modulus",

author = "Hallfors, {Nicholas G.} and Teo, {Jeremy C.M.} and Bertone, {Peter M.} and Joshi, {Chakra P.} and Ajymurat Orozaliev and Martin, {Matthew N.} and Isakovic, {A. F.}",

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year = "2022",

month = jan,

doi = "10.3390/pr10010134",

language = "English (US)",

volume = "10",

journal = "Processes",

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TY - JOUR

T1 - Electrodeformation of White Blood Cells Enriched with Gold Nanoparticles

AU - Hallfors, Nicholas G.

AU - Teo, Jeremy C.M.

AU - Bertone, Peter M.

AU - Joshi, Chakra P.

AU - Orozaliev, Ajymurat

AU - Martin, Matthew N.

AU - Isakovic, A. F.

PY - 2022/1

Y1 - 2022/1

N2 - The elasticity of white blood cells (WBCs) provides valuable insight into the condition of the cells themselves, the presence of some diseases, as well as immune system activity. In this work, we describe a novel process of refined control of WBCs’ elasticity through a combined use of gold nanoparticles (AuNPs) and the microelectrode array device. The capture and controlled deformation of gold nanoparticles enriched white blood cells in vitro are demonstrated and quantified. Gold nanoparticles enhance the effect of electrically induced deformation and make the DEP-related processes more controllable.

AB - The elasticity of white blood cells (WBCs) provides valuable insight into the condition of the cells themselves, the presence of some diseases, as well as immune system activity. In this work, we describe a novel process of refined control of WBCs’ elasticity through a combined use of gold nanoparticles (AuNPs) and the microelectrode array device. The capture and controlled deformation of gold nanoparticles enriched white blood cells in vitro are demonstrated and quantified. Gold nanoparticles enhance the effect of electrically induced deformation and make the DEP-related processes more controllable.

KW - Electrodeformation

KW - Lab-on-chip

KW - Leukocytes

KW - Nanoparticles

KW - Young’s modulus

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JO - Processes

JF - Processes

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ER -

Electrodeformation of White Blood Cells Enriched with Gold Nanoparticles

Abstract

Keywords

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