TY - JOUR
T1 - Electrophoretic capture of a DNA chain into a nanopore
AU - Rowghanian, Payam
AU - Grosberg, Alexander Y.
PY - 2013/4/29
Y1 - 2013/4/29
N2 - Based on our formulation of the DNA electrophoresis near a pore [Rowghanian and Grosberg, Phys. Rev. E (to be published)], we address the electrophoretic DNA capture into a nanopore as a steady-state process of particle absorption to a sink placed on top of an energy barrier. Reproducing the previously observed diffusion-limited and barrier-limited regimes as two different limits of the particle absorption process and matching the data, our model suggests a slower growth of the capture rate with the DNA length for very large DNA molecules than the previous model, motivating more experiments beyond the current range of electric field and DNA length. At moderately weak electric fields, our model predicts a different effect, stating that the DNA length dependence of the capture rate first disappears as the field is reduced and eventually reverses to a decreasing trend with N.
AB - Based on our formulation of the DNA electrophoresis near a pore [Rowghanian and Grosberg, Phys. Rev. E (to be published)], we address the electrophoretic DNA capture into a nanopore as a steady-state process of particle absorption to a sink placed on top of an energy barrier. Reproducing the previously observed diffusion-limited and barrier-limited regimes as two different limits of the particle absorption process and matching the data, our model suggests a slower growth of the capture rate with the DNA length for very large DNA molecules than the previous model, motivating more experiments beyond the current range of electric field and DNA length. At moderately weak electric fields, our model predicts a different effect, stating that the DNA length dependence of the capture rate first disappears as the field is reduced and eventually reverses to a decreasing trend with N.
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U2 - 10.1103/PhysRevE.87.042722
DO - 10.1103/PhysRevE.87.042722
M3 - Article
C2 - 23679464
AN - SCOPUS:84877734853
VL - 87
JO - Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
JF - Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
SN - 1063-651X
IS - 4
M1 - 042722
ER -