Emerging microengineered tools for functional analysis and phenotyping of blood cells

Xiang Li, Weiqiang Chen, Zida Li, Ling Li, Hongchen Gu, Jianping Fu

Research output: Contribution to journalReview articlepeer-review

Abstract

The available techniques for assessing blood cell functions are limited considering the various types of blood cell and their diverse functions. In the past decade, rapid advances in microengineering have enabled an array of blood cell functional measurements that are difficult or impossible to achieve using conventional bulk platforms. Such miniaturized blood cell assay platforms also provide the attractive capabilities of reducing chemical consumption, cost, and assay time, as well as exciting opportunities for device integration, automation, and assay standardization. This review summarizes these contemporary microengineered tools and discusses their promising potential for constructing accurate in vitro models and rapid clinical diagnosis using minimal amounts of whole-blood samples.

Original languageEnglish (US)
Pages (from-to)586-594
Number of pages9
JournalTrends in Biotechnology
Volume32
Issue number11
DOIs
StatePublished - Nov 1 2014

Keywords

  • Blood cell
  • Functional analysis
  • Microengineering
  • Microfluidics
  • Phenotyping

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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