End-capped α-helices as modulators of protein function

Andrew B. Mahon, Paramjit S. Arora

Research output: Contribution to journalReview articlepeer-review

Abstract

Examination of complexes of proteins with other biomolecules reveals that proteins tend to interact with partners via folded subdomains, in which the backbone possesses secondary structure. a-Helices, the largest class of protein secondary structures, play fundamental roles in a multitude of highly specific protein-protein and protein-nucleic acids interactions. Herein, we describe the potential of a helix nucleation strategy to afford modulators of protein-protein interactions.

Original languageEnglish (US)
Pages (from-to)e57-e62
JournalDrug Discovery Today: Technologies
Volume9
Issue number1
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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