Endo-selective pd-catalyzed silyl methyl heck reaction

Marvin Parasram, Viktor O. Iaroshenko, Vladimir Gevorgyan

Research output: Contribution to journalArticlepeer-review


A palladium (Pd)-catalyzed endo-selective Heck reaction of iodomethylsilyl ethers of phenols and aliphatic alkenols has been developed. Mechanistic studies reveal that this silyl methyl Heck reaction operates via a hybrid Pd-radical process and that the silicon atom is crucial for the observed endo selectivity. The obtained allylic silyloxycycles were further oxidized into (Z)-alkenyldiols.

Original languageEnglish (US)
Pages (from-to)17926-17929
Number of pages4
JournalJournal of the American Chemical Society
Issue number52
StatePublished - Dec 31 2014

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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