TY - JOUR
T1 - Endothelial function in individuals with coronary artery disease with and without type 2 diabetes mellitus
AU - Reyes-Soffer, Gissette
AU - Holleran, Steve
AU - Di Tullio, Marco R.
AU - Homma, Shunichi
AU - Boden-Albala, Bernadette
AU - Ramakrishnan, Rajasekhar
AU - Elkind, Mitchell S.
AU - Sacco, Ralph L.
AU - Ginsberg, Henry N.
N1 - Funding Information:
This study was funded by grants from the NIH/NINDS ( R27 29993 , R01 48134 ), NIH, NHLBI-JDF : P01 HL 57217 ; NIH, NCRR : M01 RR00645-25 ; and T32HL07343 .
PY - 2010/9
Y1 - 2010/9
N2 - The goal of this study was to determine if individuals with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) had greater endothelial dysfunction (ED) than individuals with only CAD. Flow-mediated dilation (FMD), calculated as percentage increase in brachial artery diameter in response to postischemic blood flow, was measured after an overnight fast in 2 cohorts. The first cohort included 76 participants in the Northern Manhattan Study with CAD; 25 also had T2DM. The second cohort was composed of 27 individuals with both T2DM and CAD who were participants in a study of postprandial lipemia. Combined, we analyzed 103 patients with CAD: 52 with T2DM (T2DM+) and 51 without T2DM (T2DM-). The 52 CAD T2DM+ subjects had a mean FMD of 3.9% ± 3.2%, whereas the 51 CAD T2DM- subjects had a greater mean FMD of 5.5% ± 4.0% (P < .03). An investigation of various confounders known to affect FMD identified age and body mass index as the only significant covariates in a multiple regression model. Adjusting for age and body mass index, we found that FMD remained lower in T2DM+ subjects compared with T2DM- subjects (difference, -1.99%; P < .03). In patients with CAD, the concomitant presence of T2DM is independently associated with greater ED, as measured by FMD. This finding may be relevant to the greater early and late morbidity and mortality observed in patients with both CAD and T2DM.
AB - The goal of this study was to determine if individuals with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) had greater endothelial dysfunction (ED) than individuals with only CAD. Flow-mediated dilation (FMD), calculated as percentage increase in brachial artery diameter in response to postischemic blood flow, was measured after an overnight fast in 2 cohorts. The first cohort included 76 participants in the Northern Manhattan Study with CAD; 25 also had T2DM. The second cohort was composed of 27 individuals with both T2DM and CAD who were participants in a study of postprandial lipemia. Combined, we analyzed 103 patients with CAD: 52 with T2DM (T2DM+) and 51 without T2DM (T2DM-). The 52 CAD T2DM+ subjects had a mean FMD of 3.9% ± 3.2%, whereas the 51 CAD T2DM- subjects had a greater mean FMD of 5.5% ± 4.0% (P < .03). An investigation of various confounders known to affect FMD identified age and body mass index as the only significant covariates in a multiple regression model. Adjusting for age and body mass index, we found that FMD remained lower in T2DM+ subjects compared with T2DM- subjects (difference, -1.99%; P < .03). In patients with CAD, the concomitant presence of T2DM is independently associated with greater ED, as measured by FMD. This finding may be relevant to the greater early and late morbidity and mortality observed in patients with both CAD and T2DM.
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U2 - 10.1016/j.metabol.2009.12.023
DO - 10.1016/j.metabol.2009.12.023
M3 - Article
C2 - 20102776
AN - SCOPUS:77956638398
SN - 0026-0495
VL - 59
SP - 1365
EP - 1371
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 9
ER -