Engineered cellular response to scaffold architecture in a rabbit trephine defect

Joshua L. Simon, Tithi Dutta Roy, J. Russell Parsons, E. Dianne Rekow, Van P. Thompson, John Kemnitzer, John L. Ricci

Research output: Contribution to journalArticle

Abstract

Tight control of pore architecture in porous scaffolds for bone repair is critical for a fully elucidated tissue response. Solid freeform fabrication (SFF) enables construction of scaffolds with tightly controlled pore architecture. Four types of porous scaffolds were constructed using SFF and evaluated in an 8-mm rabbit trephine defect at 8 and 16 weeks (n = 6): a lactide/glycolide (50:50) copolymer scaffold with 20% w/w tri-calcium phosphate and random porous architecture (Group 1); another identical design made from poly(desaminotyrosyl-tyrosine ethyl ester carbonate) [poly-(DTE carbonate)], a tyrosine-derived pseudo-polyamino acid (Group. 2); and two poly(DTE carbonate) scaffolds containing 500 μm pores separated by 500-μm thick walls, one type with solid walls (Group 3), and one type with microporous walls (Group 4). A commercially available coralline scaffold (Interpore) with a 486-μm average pore size and empty defects were used as controls. There was no significant difference in the overall amount of bone ingrowth in any of the devices, as found by radiographic analysis, but patterns of bone formation matched the morphology of the scaffold. These results suggest that controlled scaffold architecture can be superimposed on biomaterial composition to design and construct scaffolds with improved fill time.

Original languageEnglish (US)
Pages (from-to)275-282
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume66
Issue number2
DOIs
StatePublished - Aug 1 2003

Keywords

  • 3-D printing
  • Poly(DTE carbonate)
  • Porous scaffold
  • Scaffold architecture
  • Solid freeform fabrication

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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