TY - JOUR
T1 - Enhanced Brain Correlations during Rest Are Related to Memory for Recent Experiences
AU - Tambini, Arielle
AU - Ketz, Nicholas
AU - Davachi, Lila
N1 - Funding Information:
We thank K. Oschner and K. Duncan for suggestions on earlier versions of the manuscript and B. Pesaran for advice regarding the coherence analyses. This work was supported by National Institute of Mental Health Grant MH074692 and Dart Neuroscience to L.D.
PY - 2010/1/28
Y1 - 2010/1/28
N2 - Long-term storage of episodic memories is hypothesized to result from the off-line transfer of information from the hippocampus to neocortex, allowing a hippocampal-independent cortical representation to emerge. However, off-line hippocampal-cortical interactions have not been demonstrated to be linked with long-term memory. Here, using functional magnetic resonance imaging, we examined if hippocampal-cortical BOLD correlations during rest following an associative encoding task are related to later associative memory performance. Our data show enhanced functional connectivity between the hippocampus and a portion of the lateral occipital complex (LO) during rest following a task with high subsequent memory compared to pretask baseline resting connectivity. This effect is not seen during rest following a task with poor subsequent memory. Furthermore, the magnitude of hippocampal-LO correlations during posttask rest predicts individual differences in later associative memory. These results demonstrate the importance of postexperience resting brain correlations for memory for recent experiences. Video Abstract: {An electronic component is presented}.
AB - Long-term storage of episodic memories is hypothesized to result from the off-line transfer of information from the hippocampus to neocortex, allowing a hippocampal-independent cortical representation to emerge. However, off-line hippocampal-cortical interactions have not been demonstrated to be linked with long-term memory. Here, using functional magnetic resonance imaging, we examined if hippocampal-cortical BOLD correlations during rest following an associative encoding task are related to later associative memory performance. Our data show enhanced functional connectivity between the hippocampus and a portion of the lateral occipital complex (LO) during rest following a task with high subsequent memory compared to pretask baseline resting connectivity. This effect is not seen during rest following a task with poor subsequent memory. Furthermore, the magnitude of hippocampal-LO correlations during posttask rest predicts individual differences in later associative memory. These results demonstrate the importance of postexperience resting brain correlations for memory for recent experiences. Video Abstract: {An electronic component is presented}.
KW - SYSNEURO
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U2 - 10.1016/j.neuron.2010.01.001
DO - 10.1016/j.neuron.2010.01.001
M3 - Article
C2 - 20152133
AN - SCOPUS:74549191147
SN - 0896-6273
VL - 65
SP - 280
EP - 290
JO - Neuron
JF - Neuron
IS - 2
ER -