Enhanced cooperativity in hydrolytic kinetic resolution of epoxides using poly(styrene) resin-supported dendronized co-(salen) catalysts

Poorva Goyal, Xiaolai Zheng, Marcus Weck

Research output: Contribution to journalArticle

Abstract

Excellent enantioselectivities and isolated yields have been achieved for the hydrolytic kinetic resolution of epoxides using a resin-supported dendronized R,R-(salen)Co catalyst with catalyst loadings as low as 0.04 mol%, the lowest metal loadings of any heterogeneous resin-supported (salen)Co catalyst reported to date. In addition, the supported catalysts can be recycled and reused with comparable enantioselectivities. It is hypothesized that the high catalytic activity can be attributed to the flexible linker and the dendronized framework supporting the (salen)Co moieties on the resin thereby promoting cooperativity between two metal centers. This work opens up new opportunities for the design of highly active resin-supported catalysts that catalyze transformations through a bimetallic pathway.

Original languageEnglish (US)
Pages (from-to)1816-1822
Number of pages7
JournalAdvanced Synthesis and Catalysis
Volume350
Issue number11-12
DOIs
StatePublished - Aug 4 2008

Keywords

  • Asymmetric catalysis
  • Cobalt
  • Epoxides
  • Hydrolytic kinetic resolution
  • Salen ligand

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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