TY - JOUR
T1 - Enhanced neuronal response induced by fast inhibition
AU - Dodla, Ramana
AU - Rinzel, John
PY - 2006/1
Y1 - 2006/1
N2 - We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation with a favorable timing and counterintuitively induces a reduction of the spike threshold. The basic mechanism is also illustrated with the phaseplane analysis of a two variable model.
AB - We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation with a favorable timing and counterintuitively induces a reduction of the spike threshold. The basic mechanism is also illustrated with the phaseplane analysis of a two variable model.
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U2 - 10.1103/PhysRevE.73.010903
DO - 10.1103/PhysRevE.73.010903
M3 - Article
C2 - 16486114
AN - SCOPUS:32844460635
SN - 1063-651X
VL - 73
JO - Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
JF - Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
IS - 1
M1 - 010903
ER -