Enhanced neuronal response induced by fast inhibition

Ramana Dodla, John Rinzel

Research output: Contribution to journalArticlepeer-review

Abstract

We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation with a favorable timing and counterintuitively induces a reduction of the spike threshold. The basic mechanism is also illustrated with the phaseplane analysis of a two variable model.

Original languageEnglish (US)
Article number010903
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume73
Issue number1
DOIs
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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