Enhanced neuronal response induced by fast inhibition

Ramana Dodla; John Rinzel

doi:10.1103/PhysRevE.73.010903

Enhanced neuronal response induced by fast inhibition

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Abstract

We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation with a favorable timing and counterintuitively induces a reduction of the spike threshold. The basic mechanism is also illustrated with the phaseplane analysis of a two variable model.

Original language	English (US)
Article number	010903
Journal	Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume	73
Issue number	1
DOIs	https://doi.org/10.1103/PhysRevE.73.010903
State	Published - Jan 2006

ASJC Scopus subject areas

Statistical and Nonlinear Physics
Statistics and Probability
Condensed Matter Physics

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10.1103/PhysRevE.73.010903

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Enhanced neuronal response induced by fast inhibition

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