Enhanced neuronal response induced by fast inhibition

Ramana Dodla; John Rinzel

doi:10.1103/PhysRevE.73.010903

Enhanced neuronal response induced by fast inhibition

Ramana Dodla, John Rinzel

Research output: Contribution to journal › Article › peer-review

Abstract

We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation with a favorable timing and counterintuitively induces a reduction of the spike threshold. The basic mechanism is also illustrated with the phaseplane analysis of a two variable model.

Original language	English (US)
Article number	010903
Journal	Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume	73
Issue number	1
DOIs	https://doi.org/10.1103/PhysRevE.73.010903
State	Published - Jan 2006

ASJC Scopus subject areas

Statistical and Nonlinear Physics
Statistics and Probability
Condensed Matter Physics

Access to Document

10.1103/PhysRevE.73.010903

Cite this

@article{de5cc38d087b498bacbdfcac0994739d,

title = "Enhanced neuronal response induced by fast inhibition",

abstract = "We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation with a favorable timing and counterintuitively induces a reduction of the spike threshold. The basic mechanism is also illustrated with the phaseplane analysis of a two variable model.",

author = "Ramana Dodla and John Rinzel",

year = "2006",

month = jan,

doi = "10.1103/PhysRevE.73.010903",

language = "English (US)",

volume = "73",

journal = "Physical Review E - Statistical, Nonlinear, and Soft Matter Physics",

issn = "1539-3755",

publisher = "American Physical Society",

number = "1",

}

TY - JOUR

T1 - Enhanced neuronal response induced by fast inhibition

AU - Dodla, Ramana

AU - Rinzel, John

PY - 2006/1

Y1 - 2006/1

N2 - We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation with a favorable timing and counterintuitively induces a reduction of the spike threshold. The basic mechanism is also illustrated with the phaseplane analysis of a two variable model.

AB - We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation with a favorable timing and counterintuitively induces a reduction of the spike threshold. The basic mechanism is also illustrated with the phaseplane analysis of a two variable model.

UR - http://www.scopus.com/inward/record.url?scp=32844460635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32844460635&partnerID=8YFLogxK

U2 - 10.1103/PhysRevE.73.010903

DO - 10.1103/PhysRevE.73.010903

M3 - Article

C2 - 16486114

AN - SCOPUS:32844460635

SN - 1539-3755

VL - 73

JO - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

JF - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

IS - 1

M1 - 010903

ER -

Enhanced neuronal response induced by fast inhibition

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this