A case of eosinophilic granuloma of the jawbone is presented. The involved teeth had periapical lesions that, according to radiographic examination after endodontic therapy, had healed after approximately four years. Thereafter, the patient had skin, genital, and respiratory infections. At this time, radiographs showed extensive radiolucency of the previously healed areas and simultaneous elevation of temperature. The biopsy specimen showed the typical features of an eosinophilic granuloma. After radiotherapy and loss of one of the involved teeth, the lesions healed.
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