@article{c0c6a7422a424d9aaee51a07a4341027,
title = "Epigenetic signatures may explain the relationship between socioeconomic position and risk of mental illness: Preliminary findings from an urban community-based sample",
abstract = "Low socioeconomic position (SEP) has previously been linked to a number of negative health indicators, including poor mental health. The biologic mechanisms linking SEP and mental health remain poorly understood. Recent work suggests that social exposures influence DNA methylation in a manner salient to mental health. We conducted a pilot investigation to assess whether SEP, measured as educational attainment, modifies the association between genomic methylation profiles and traumatic stress in a trauma-exposed sample. Results show that methylation × SEP interactions occur preferentially in genes pertaining to nervous system function, suggesting a plausible biological pathway by which SEP may enhance sensitivity to stress and, in turn, risk of posttraumatic stress disorder.[Supplementary materials are available for this article. Go to the publisher's online edition of Biodemography and Social Biology for the following free supplemental resource: Supplementary tables of full model and functional annotation clustering results.]",
author = "Monica Uddin and Sandro Galea and Chang, {Shun Chiao} and Koenen, {Karestan C.} and Emily Goldmann and Wildman, {Derek E.} and Aiello, {Allison E.}",
note = "Funding Information: We thank Rebecca M. Coulborn for overseeing DNHS specimen collection, Janie Slayden for coordinating the overall DNHS project, and Amy Weckle and Richelo Soliven for handling the DNHS specimen processing and laboratory technical assistance. We thank the many Detroit residents who chose to participate in the DNHS, and Jorge Delva, Larry Gant, Bob Marans, and Trivellore Raghunathan for contributing to the conceptual development of the DNHS. We also thank Dr. Sue Land and her staff at the Wayne State University Applied Genomic Technology Center for running microarrays. This study was supported by National Institutes of Health Grants DA022720, DA022720-S1, and MH08828. Additional support was provided by the Robert Wood Johnson Health and Society Scholars Small Grant Program and the University of Michigan Office of the Vice President for Research Faculty Grants and Awards Program, as well as by the Wayne State University Research Excellence Fund.",
year = "2013",
month = jan,
day = "1",
doi = "10.1080/19485565.2013.774627",
language = "English (US)",
volume = "59",
pages = "68--84",
journal = "Biodemography and Social Biology",
issn = "1948-5565",
publisher = "Taylor and Francis Ltd.",
number = "1",
}