Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes

Sankar Swaminathan; Brandon S. Huneycutt; Carol S. Reiss; Elliott Kieff

Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes

Sankar Swaminathan, Brandon S. Huneycutt, Carol S. Reiss, Elliott Kieff

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

The recent derivation of otherwise isogenic Epstein-Barr virus (EBV) recombinants carrying or lacking the EBV small RNA (EBER) genes enabled us to test whether EBERs are similar to adenovirus VA RNAs in modulating interferon (IFN) effects on virus infection. EBER-positive and -negative EBV recombinants did not differ in their sensitivity to alpha interferon (IFN-α)- or LFN-γ-mediated inhibition of lymphocyte growth transformation. In addition, EBERs did not decrease the inhibitory effects of IFN on vesicular stomatitis virus replication in EBV-transformed lymphocytes. EBER deletion also did not render EBV-transformed B lymphocytes susceptible to an IFN effect on cell proliferation or EBV replication.

Original language	English (US)
Pages (from-to)	5133-5136
Number of pages	4
Journal	Journal of virology
Volume	66
Issue number	8
State	Published - Aug 1992

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

Cite this

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title = "Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes",

abstract = "The recent derivation of otherwise isogenic Epstein-Barr virus (EBV) recombinants carrying or lacking the EBV small RNA (EBER) genes enabled us to test whether EBERs are similar to adenovirus VA RNAs in modulating interferon (IFN) effects on virus infection. EBER-positive and -negative EBV recombinants did not differ in their sensitivity to alpha interferon (IFN-α)- or LFN-γ-mediated inhibition of lymphocyte growth transformation. In addition, EBERs did not decrease the inhibitory effects of IFN on vesicular stomatitis virus replication in EBV-transformed lymphocytes. EBER deletion also did not render EBV-transformed B lymphocytes susceptible to an IFN effect on cell proliferation or EBV replication.",

author = "Sankar Swaminathan and Huneycutt, {Brandon S.} and Reiss, {Carol S.} and Elliott Kieff",

year = "1992",

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journal = "Journal of virology",

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AU - Reiss, Carol S.

AU - Kieff, Elliott

PY - 1992/8

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N2 - The recent derivation of otherwise isogenic Epstein-Barr virus (EBV) recombinants carrying or lacking the EBV small RNA (EBER) genes enabled us to test whether EBERs are similar to adenovirus VA RNAs in modulating interferon (IFN) effects on virus infection. EBER-positive and -negative EBV recombinants did not differ in their sensitivity to alpha interferon (IFN-α)- or LFN-γ-mediated inhibition of lymphocyte growth transformation. In addition, EBERs did not decrease the inhibitory effects of IFN on vesicular stomatitis virus replication in EBV-transformed lymphocytes. EBER deletion also did not render EBV-transformed B lymphocytes susceptible to an IFN effect on cell proliferation or EBV replication.

AB - The recent derivation of otherwise isogenic Epstein-Barr virus (EBV) recombinants carrying or lacking the EBV small RNA (EBER) genes enabled us to test whether EBERs are similar to adenovirus VA RNAs in modulating interferon (IFN) effects on virus infection. EBER-positive and -negative EBV recombinants did not differ in their sensitivity to alpha interferon (IFN-α)- or LFN-γ-mediated inhibition of lymphocyte growth transformation. In addition, EBERs did not decrease the inhibitory effects of IFN on vesicular stomatitis virus replication in EBV-transformed lymphocytes. EBER deletion also did not render EBV-transformed B lymphocytes susceptible to an IFN effect on cell proliferation or EBV replication.

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Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes

Abstract

ASJC Scopus subject areas

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