Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes

Sankar Swaminathan, Brandon S. Huneycutt, Carol S. Reiss, Elliott Kieff

Research output: Contribution to journalComment/debate

Abstract

The recent derivation of otherwise isogenic Epstein-Barr virus (EBV) recombinants carrying or lacking the EBV small RNA (EBER) genes enabled us to test whether EBERs are similar to adenovirus VA RNAs in modulating interferon (IFN) effects on virus infection. EBER-positive and -negative EBV recombinants did not differ in their sensitivity to alpha interferon (IFN- α)- or IFN-γ-mediated inhibition of lymphocyte growth transformation. In addition, EBERs did not decrease the inhibitory effects of IFN on vesicular stomatitis virus replication in EBV-transformed lymphocytes. EBER deletion also did not render EBV-transformed B lymphocytes susceptible to an IFN effect on cell proliferation or EBV replication.

Original languageEnglish (US)
Pages (from-to)5133-5136
Number of pages4
JournalJournal of virology
Volume66
Issue number8
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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