@inbook{7c9f57ed7d144394becedd3bfdb23fa9,
title = "Equilibrium statistical mechanics, non-hamiltonian molecular dynamics, and novel applications from resonance-free timesteps to adiabatic free energy dynamics",
abstract = "Levinthal's paradox [1,2], first introduced in the 1960's (early in the childhood of simulations in Chemistry), serves as a good illustration of the limitations we still face in the application of molecular dynamics (MD). Levinthal reasoned that if we were to assume that every residue in a polypeptide has a least two stable conformations, then a small 100 residue polypeptide would have 2 100 possible states. If we were to study such a protein using traditional, state of the art, MD techniques, the native state would only be deduced after a little more than a billion years.",
author = "Abrams, {J. B.} and Tuckerman, {Mark E.} and Martyna, {G. J.}",
year = "2006",
doi = "10.1007/3-540-35273-2_5",
language = "English (US)",
isbn = "3540352708",
series = "Lecture Notes in Physics",
pages = "139--192",
editor = "Mauro Ferrario and Giovanni Ciccotti and Kurt Binder",
booktitle = "Computer Simulations in Condensed Matter Systems",
}