TY - JOUR
T1 - Establishing the pre-placodal region and breaking it into placodes with distinct identities
AU - Saint-Jeannet, Jean Pierre
AU - Moody, Sally A.
N1 - Funding Information:
We would like to thank Marianne Bronner, Carole LaBonne and the Fondation des Treilles for organizing the meeting that is at the origin of this review. Work in the authors׳ laboratories is supported by NIH ( R01 DE014212 to J.-P.S.-J. and R01 DE022065 to S.A.M.).
PY - 2014/5/1
Y1 - 2014/5/1
N2 - Specialized sensory organs in the vertebrate head originate from thickenings in the embryonic ectoderm called cranial sensory placodes. These placodes, as well as the neural crest, arise from a zone of ectoderm that borders the neural plate. This zone separates into a precursor field for the neural crest that lies adjacent to the neural plate, and a precursor field for the placodes, called the pre-placodal region (PPR), that lies lateral to the neural crest. The neural crest domain and the PPR are established in response to signaling events mediated by BMPs, FGFs and Wnts, which differentially activate transcription factors in these territories. In the PPR, members of the Six and Eya families, act in part to repress neural crest specific transcription factors, thus solidifying a placode developmental program. Subsequently, in response to environmental cues the PPR is further subdivided into placodal territories with distinct characteristics, each expressing a specific repertoire of transcription factors that provide the necessary information for their progression to mature sensory organs. In this review we summarize recent advances in the characterization of the signaling molecules and transcriptional effectors that regulate PPR specification and its subdivision into placodal domains with distinct identities.
AB - Specialized sensory organs in the vertebrate head originate from thickenings in the embryonic ectoderm called cranial sensory placodes. These placodes, as well as the neural crest, arise from a zone of ectoderm that borders the neural plate. This zone separates into a precursor field for the neural crest that lies adjacent to the neural plate, and a precursor field for the placodes, called the pre-placodal region (PPR), that lies lateral to the neural crest. The neural crest domain and the PPR are established in response to signaling events mediated by BMPs, FGFs and Wnts, which differentially activate transcription factors in these territories. In the PPR, members of the Six and Eya families, act in part to repress neural crest specific transcription factors, thus solidifying a placode developmental program. Subsequently, in response to environmental cues the PPR is further subdivided into placodal territories with distinct characteristics, each expressing a specific repertoire of transcription factors that provide the necessary information for their progression to mature sensory organs. In this review we summarize recent advances in the characterization of the signaling molecules and transcriptional effectors that regulate PPR specification and its subdivision into placodal domains with distinct identities.
KW - BMP
KW - Cranial sensory placodes
KW - Eya
KW - FGF
KW - Gene regulatory network
KW - Pax
KW - Pre-placodal ectoderm
KW - Six
KW - Wnt
UR - http://www.scopus.com/inward/record.url?scp=84897448226&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897448226&partnerID=8YFLogxK
U2 - 10.1016/j.ydbio.2014.02.011
DO - 10.1016/j.ydbio.2014.02.011
M3 - Article
C2 - 24576539
AN - SCOPUS:84897448226
SN - 0012-1606
VL - 389
SP - 13
EP - 27
JO - Developmental Biology
JF - Developmental Biology
IS - 1
ER -