Estimating the number of deaths with rotavirus as a cause in England and Wales

Mark Jit, Richard Pebody, Mark Chen, Nick Andrews, W. John Edmunds

Research output: Contribution to journalArticlepeer-review

Abstract

The precise number of deaths due to rotavirus infection in England and Wales is difficult to determine because mortality is usually low and reported simply as death due to gastrointestinal disease. We have used two independent methods to estimate this figure. Firstly, we obtained records from the Office for National Statistics of deaths in children with any mention of gastroenteritis. For deaths with uncertain aetiology, we estimated the proportion attributable to rotavirus using a linear model with monthly laboratory reports of gastrointestinal micro-organisms as predictors. Secondly, we calculated the case-fatality ratio of records in Hospital Episode Statistics with rotavirus indicated, and applied this ratio to an estimate of the actual number of rotavirus hospital admissions. The two methods gave estimates of 3.3 and 3.2 rotavirus deaths a year respectively.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalHuman Vaccines
Volume3
Issue number1
DOIs
StatePublished - 2007

Keywords

  • Child mortality
  • Gastroenterititis
  • Regression analysis
  • Rotavirus
  • Rotavirus vaccines (all MeSH terms)

ASJC Scopus subject areas

  • Immunology
  • General Pharmacology, Toxicology and Pharmaceutics

Fingerprint

Dive into the research topics of 'Estimating the number of deaths with rotavirus as a cause in England and Wales'. Together they form a unique fingerprint.

Cite this