Ethical considerations in conducting pragmatic trials in oncology

Marilyn J. Hammer

Research output: Contribution to journalReview articlepeer-review


Pragmatic trials evaluate interventions in real-life scenarios, which differ from explanatory trials that control for numerous factors and variables to best determine causal associations. Each approach has advantages and disadvantages. Conducting pragmatic research trials while maintaining the tenets of the ethical conduct of research can sometimes be challenging, particularly regarding informed consent. In this column, distinctions between pragmatic and explanatory trials are discussed from an ethical view.

Original languageEnglish (US)
Pages (from-to)537-539
Number of pages3
JournalOncology nursing forum
Issue number5
StatePublished - Sep 2017


  • Ethics
  • Pragmatic and explanatory trials
  • Research

ASJC Scopus subject areas

  • Oncology(nursing)


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