Ethnic and gender differences in advanced glycation end products measured by skin auto-fluorescence

Marjonneke J. Mook-Kanamori, Mohammed M. El-Din Selim, Ahmed H. Takiddin, Hala Al-Homsi, Khoulood A.S. Al-Mahmoud, Amina Al-Obaidli, Mahmoud A. Zirie, Jillian Rowe, Wafaa Sekkal Gherbi, Omar M. Chidiac, Sara Abdul Kader, Wadha A.Al Muftah, Cindy McKeon, Karsten Suhre, Dennis O. Mook-Kanamori

Research output: Contribution to journalArticlepeer-review


Advanced glycation end products (AGEs) have been shown to be a predictor of cardiovascular risk in Caucasian subjects. In this study we examine whether the existing reference values are useable for non-Caucasian ethnicities. Furthermore, we assessed whether gender and smoking affect AGEs. Methods: AGEs were determined by a non-invasive method of skin auto-fluorescence (AF). AF was measured in 200 Arabs, 99 South Asians, 35 Filipinos and 14 subjects of other/mixed ethnicity in the Qatar Metabolomics Study on Diabetes (QMDiab). Using multivariate linear regression analysis and adjusting for age and type 2 diabetes, we assessed whether ethnicity, gender and smoking were associated with AF. Results: The mean AF was 2.27 arbitrary units (AU) (SD: 0.63). Arabs and Filipinos had a significant higher AF than the South Asian population (0.25 arbitrary units (AU) (95% CI: 0.11*0.39), p = 0.001 and 0.34 (95% CI: 0.13*0.55), p = 0.001 respectively). Also, AF was significantly higher in females (0.41 AU (95% CI: 0.29*0.53), p 0.001). AF associated with smoking (0.21 AU (95% CI: 0.01*0.41), p = 0.04) and increased with the number of pack-years smoked (p = 0.02). Conclusions: This study suggests that the existing reference values should take ethnicity, gender and smoking into account. Larger studies in specific ethnicities are necessary to create ethnic-and gender-specific reference values.

Original languageEnglish (US)
Pages (from-to)325-330
Number of pages6
Issue number2
StatePublished - Apr 2013


  • Advanced glycation endproducts
  • Epidemiology
  • Ethnicity
  • Gender differences
  • Skin auto-fluorescence
  • Smoking
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Dermatology


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