Evaluating pulsatile ocular blood flow analysis in normal and treated glaucomatous eyes

Ali Aydin, Gadi Wollstein, Lori Lyn Price, Joel S. Schuman

    Research output: Contribution to journalArticle

    Abstract

    PURPOSE: To evaluate pulsatile ocular blood flow (POBF) analysis in normal subjects and glaucoma patients by comparison of POBF measurements with functional (as determined by visual field [VF]) and structural (as determined by optical coherence tomography [OCT]) measures. DESIGN: Prospective, cross-sectional study. METHODS: Forty-one eyes of 24 consecutive glaucoma patients and 20 eyes of 10 healthy subjects were studied; POBF analysis was performed on all subjects at the same visit as VF testing and OCT retinal nerve fiber layer (NFL) thickness measurement. The mean results of normal and glaucomatous eyes were compared for each method. Correlation between measurements obtained with each modality and the discriminating power using receiver operator characteristic curves was tested. RESULTS: The mean POBF (standard deviation [SD]) in the normal group was 1,010.4 (292.8) μl/min and 989.3 (305.5) μl/min in the glaucoma group (P = .90). Significant differences between groups were found for VF mean deviation and pattern standard deviation (P = .02, P = .004, respectively) and OCT mean NFL thickness (P < .0001). No correlation was found between POBF parameters and intraocular pressure, VF, or OCT variables except for intraocular pressure in glaucoma group (r = -.43, P = .003). The area under the receiver operator characteristic curves was higher for VF indexes and OCT mean NFL thickness than POBF parameters for distinguishing between normal and glaucomatous eyes. CONCLUSIONS: The wide range of normal values and the low discriminating power of POBF between normal and glaucomatous eyes limits the clinical use of the device for glaucoma patients.

    Original languageEnglish (US)
    Pages (from-to)448-453
    Number of pages6
    JournalAmerican Journal of Ophthalmology
    Volume136
    Issue number3
    DOIs
    StatePublished - Sep 1 2003

    ASJC Scopus subject areas

    • Ophthalmology

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