Evaluation of collagen-based membranes for guided bone regeneration, by three-dimensional computerized microtomography

Paulo Guilherme Coelho; Gabriela Giro; Wanki Kim; Rodrigo Granato; Charles Marin; Estevam Augusto Bonfante; Samara Bonfante; Thomas Lilin; Marcelo Suzuki

doi:10.1016/j.oooo.2011.11.032

Evaluation of collagen-based membranes for guided bone regeneration, by three-dimensional computerized microtomography

Paulo Guilherme Coelho, Gabriela Giro, Wanki Kim, Rodrigo Granato, Charles Marin, Estevam Augusto Bonfante, Samara Bonfante, Thomas Lilin, Marcelo Suzuki

Biomaterials and Biomimetics

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The aim of this study was to evaluate the use of a collagen-based membrane compared with no treatment on guided bone regeneration by 3-dimensional computerized microtomography (μCT). Study Design: Defects were created between the mesial and distal premolar roots of the second and third premolars (beagle dogs; n = 8). A collagen-based membrane (Vitala; Osteogenics Biomedical Inc., TX, USA) was placed in one of the defects (membrane group; n = 16), and the other was left untreated (no-membrane group; n = 16). Left and right sides provided healing samples for 2 and 16 weeks. Three-dimensional bone architecture was acquired by μCT and categorized as fully regenerated (F, bone height and width) or nonregenerated (N). Results: Chi-square tests (95% level of significance) showed that tooth did not have an effect on outcome (P =.5). Significantly higher F outcomes were observed at 16 weeks than 2 weeks (P =.008) and in membrane group than in no-membrane group (P =.008). Conclusions: The collagen-based membrane influenced bone regeneration at the furcation.

Original language	English (US)
Pages (from-to)	437-443
Number of pages	7
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	114
Issue number	4
DOIs	https://doi.org/10.1016/j.oooo.2011.11.032
State	Published - Oct 2012

ASJC Scopus subject areas

Surgery
Oral Surgery
Pathology and Forensic Medicine
Dentistry (miscellaneous)
Radiology Nuclear Medicine and imaging

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Evaluation of collagen-based membranes for guided bone regeneration, by three-dimensional computerized microtomography. / Coelho, Paulo Guilherme; Giro, Gabriela; Kim, Wanki; Granato, Rodrigo; Marin, Charles; Bonfante, Estevam Augusto; Bonfante, Samara; Lilin, Thomas; Suzuki, Marcelo.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 114, No. 4, 10.2012, p. 437-443.

Research output: Contribution to journal › Article › peer-review

Coelho, Paulo Guilherme ; Giro, Gabriela ; Kim, Wanki ; Granato, Rodrigo ; Marin, Charles ; Bonfante, Estevam Augusto ; Bonfante, Samara ; Lilin, Thomas ; Suzuki, Marcelo. / Evaluation of collagen-based membranes for guided bone regeneration, by three-dimensional computerized microtomography. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2012 ; Vol. 114, No. 4. pp. 437-443.

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abstract = "Objective: The aim of this study was to evaluate the use of a collagen-based membrane compared with no treatment on guided bone regeneration by 3-dimensional computerized microtomography (μCT). Study Design: Defects were created between the mesial and distal premolar roots of the second and third premolars (beagle dogs; n = 8). A collagen-based membrane (Vitala; Osteogenics Biomedical Inc., TX, USA) was placed in one of the defects (membrane group; n = 16), and the other was left untreated (no-membrane group; n = 16). Left and right sides provided healing samples for 2 and 16 weeks. Three-dimensional bone architecture was acquired by μCT and categorized as fully regenerated (F, bone height and width) or nonregenerated (N). Results: Chi-square tests (95% level of significance) showed that tooth did not have an effect on outcome (P =.5). Significantly higher F outcomes were observed at 16 weeks than 2 weeks (P =.008) and in membrane group than in no-membrane group (P =.008). Conclusions: The collagen-based membrane influenced bone regeneration at the furcation.",

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