Evaluation of DTI property maps as basis of DTI atlas building

Zhexing Liu, Casey Goodlett, Guido Gerig, Martin Styner

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Compared to region of interest based DTI analysis, voxel-based analysis gives higher degree of localization and avoids the procedure of manual delineation with the resulting intra and inter-rater variability. One of the major challenges in voxel-wise DTI analysis is to get high quality voxel-level correspondence. For that purpose, current DTI analysis tools are building on nonlinear registration algorithms that deform individual datasets into a template image that is either precomputed or computed as part of the analysis. A variety of matching criteria and deformation schemes have been proposed, but often comparative evaluation is missing. In our opinion, the use of consistent and unbiased measures to evaluate current DTI procedures is of great importance and our work presents two possible measures. Specifically, we propose the evaluation criteria generalization and specificity, originally introduced by the shape modeling community, to evaluate and compare different DTI nonlinear warping results. These measures are of indirect nature and have a population wise view. Both measures incorporate information of the variability of the registration results in the template space via a voxel-wise PCA model. Thus far, we have used these measures to evaluate our own DTI analysis procedure employing fluid-based registration on scalar DTI maps. Generalization and specificity from tensor images in the template space were computed for 8 scalar property maps. We found that for our procedure an intensity-normalized FA feature outperformed the other scalar measurements. Also, using the tensor images rather than the FA maps as a comparison frame seemed to produce more robust results.

    Original languageEnglish (US)
    Title of host publicationMedical Imaging 2010
    Subtitle of host publicationImage Processing
    EditionPART 1
    DOIs
    StatePublished - 2010
    EventMedical Imaging 2010: Image Processing - San Diego, CA, United States
    Duration: Feb 14 2010Feb 16 2010

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    NumberPART 1
    Volume7623
    ISSN (Print)1605-7422

    Other

    OtherMedical Imaging 2010: Image Processing
    CountryUnited States
    CitySan Diego, CA
    Period2/14/102/16/10

    Keywords

    • Diffusion Tensor Imaging
    • Model Generalization
    • Model Specificity
    • Nonlinear Registration
    • Principal Component Analysis
    • Voxel-wise Analysis

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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  • Cite this

    Liu, Z., Goodlett, C., Gerig, G., & Styner, M. (2010). Evaluation of DTI property maps as basis of DTI atlas building. In Medical Imaging 2010: Image Processing (PART 1 ed.). [762325] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7623, No. PART 1). https://doi.org/10.1117/12.844911