Evaluation of Fourier transform coefficients for the diagnosis of rheumatoid arthritis from diffuse optical tomography images

Ludguier D. Montejo, Jingfei Jia, Hyun K. Kim, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We apply the Fourier Transform to absorption and scattering coefficient images of proximal interphalangeal (PIP) joints and evaluate the performance of these coefficients as classifiers using receiver operator characteristic (ROC) curve analysis. We find 25 features that yield a Youden index over 0.7, 3 features that yield a Youden index over 0.8, and 1 feature that yields a Youden index over 0.9 (90.0% sensitivity and 100% specificity). In general, scattering coefficient images yield better one-dimensional classifiers compared to absorption coefficient images. Using features derived from scattering coefficient images we obtain an average Youden index of 0.58 ± 0.16, and an average Youden index of 0.45 ± 0.15 when using features from absorption coefficient images.

    Original languageEnglish (US)
    Title of host publicationOptical Tomography and Spectroscopy of Tissue X
    DOIs
    StatePublished - 2013
    EventOptical Tomography and Spectroscopy of Tissue X - San Francisco, CA, United States
    Duration: Feb 3 2013Feb 6 2013

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume8578
    ISSN (Print)1605-7422

    Conference

    ConferenceOptical Tomography and Spectroscopy of Tissue X
    CountryUnited States
    CitySan Francisco, CA
    Period2/3/132/6/13

    Keywords

    • Computer-Aided Diagnosis
    • Diffuse Optical Tomography
    • Rheumatoid Arthritis

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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