Evaluation of SLE arthritis using frequency domain optical imaging

Alessandro Marone, Wei Tang, Youngwan Kim, Tommy Chen, George Danias, Cathy Guo, Yevgeniya Gartshteyn, Leila Khalili, Hyun Kim, Andreas Hielscher, Anca D. Askanase

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objectives Systemic lupus erythematosus (SLE) affects the joints in up to 95% of patients. The diagnosis and evaluation of SLE arthritis remain challenging in both practice and clinical trials. Frequency domain optical imaging (FDOI) has been previously used to assess joint involvement in inflammatory arthritis. The objective of this study was to evaluate FDOI in SLE arthritis. Methods Ninety-six proximal interphalangeal (PIP) joints from 16 patients with SLE arthritis and 60 PIP joints from 10 age-matched, gender-matched and race/ethnicity-matched controls were examined. A laser beam with a wavelength of 670 nm, 1 mm in diameter and intensity modulated at 300 MHz and 600 MHz was directed onto the dorsal surface of each joint, scanning across a sagittal plane. The transmitted light intensities and phase shifts were measured with an intensified charge-coupled device camera. The data were analysed using Discriminant Analysis and Support Vector Machine algorithms. Results The amplitude and phase of the transmitted light were significantly different between SLE and control PIPs (p<0.05). Receiver operating characteristic (ROC) analysis of cross-validated models showed an Area Under the ROC Curve (AUC)of 0.89 with corresponding sensitivity of 95%, specificity of 79%, and accuracy of 80%. Conclusion This study is the first evaluation of optical methods in the assessment of SLE arthritis; there was a statistically significant difference in the FDOI signals between patients with SLE and healthy volunteers. The results show that FDOI may have the potential to provide an objective, user-independent, evaluation of SLE PIP joints arthritis.

    Original languageEnglish (US)
    Article numbere000495
    JournalLupus Science and Medicine
    Volume8
    Issue number1
    DOIs
    StatePublished - Aug 30 2021

    Keywords

    • arthritis
    • inflammation
    • Lupus erythematosus
    • systemic

    ASJC Scopus subject areas

    • Immunology

    Fingerprint

    Dive into the research topics of 'Evaluation of SLE arthritis using frequency domain optical imaging'. Together they form a unique fingerprint.

    Cite this