Evaluation of triazolamers as active site inhibitors of HIV-1 protease

Andrea L. Jochim, Stephen E. Miller, Nicholas G. Angelo, Paramjit S. Arora

Research output: Contribution to journalArticlepeer-review


Proteases typically recognize their peptide substrates in extended conformations. General approaches for designing protease inhibitors often consist of peptidomimetics that feature this conformation. Herein we discuss a combination of computational and experimental studies to evaluate the potential of triazole-linked β-strand mimetics as inhibitors of HIV-1 protease activity.

Original languageEnglish (US)
Pages (from-to)6023-6026
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number21
StatePublished - Nov 1 2009


  • Peptidomimetics
  • Protease inhibitor
  • β-Strand mimetics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


Dive into the research topics of 'Evaluation of triazolamers as active site inhibitors of HIV-1 protease'. Together they form a unique fingerprint.

Cite this