Evidence, in uremic man, of the role of beta 2 adrenergic receptors in the secretion of parathyroid hormone and calcitonin (author's transl)

B. Coevoet, G. Lambrey, J. F. de Fremont, J. M. Hardin, C. Desplan, C. Calmette, R. Makdassi, M. Andrejak, M. S. Moukhtar, A. Fournier

Research output: Contribution to journalArticle

Abstract

In order to determine the effect of beta-blocking agents on secretions of parathyroid hormone and calcitonin, 9 patients with renal failure were given single doses of propranolol (a blocker of the beta 1 and beta 2 receptors) or an equivalent amount of metoprolol (a beta 1 selective agent). Propranolol causes a decrease of plasma parathyroid hormone (p less than 0.02) as well as of calcitonin (p less than 0.05) whereas metoprolol has no effect on the plasma levels of these hormones. These findings suggest that parathyroid tissue and thyroid C cells have receptors that are exclusively of the beta 2 type which are modulating the secretion of parathyroid hormone and calcitonin.
Original languageUndefined
Pages (from-to)34-6
JournalNephrologie
Volume1
Issue number1
StatePublished - 1980

Keywords

  • Adult Calcitonin/*secretion Female Heart Rate/drug effects Humans Kidney Diseases/*physiopathology Male Metoprolol Parathyroid Hormone/*secretion Phosphates/metabolism Propranolol Receptors, Adrenergic/*physiology Receptors, Adrenergic, beta/*physiology Uremia/physiopathology

Cite this

Coevoet, B., Lambrey, G., de Fremont, J. F., Hardin, J. M., Desplan, C., Calmette, C., Makdassi, R., Andrejak, M., Moukhtar, M. S., & Fournier, A. (1980). Evidence, in uremic man, of the role of beta 2 adrenergic receptors in the secretion of parathyroid hormone and calcitonin (author's transl). Nephrologie, 1(1), 34-6.