In order to determine the effect of beta-blocking agents on secretions of parathyroid hormone and calcitonin, 9 patients with renal failure were given single doses of propranolol (a blocker of the beta 1 and beta 2 receptors) or an equivalent amount of metoprolol (a beta 1 selective agent). Propranolol causes a decrease of plasma parathyroid hormone (p less than 0.02) as well as of calcitonin (p less than 0.05) whereas metoprolol has no effect on the plasma levels of these hormones. These findings suggest that parathyroid tissue and thyroid C cells have receptors that are exclusively of the beta 2 type which are modulating the secretion of parathyroid hormone and calcitonin.
|State||Published - 1980|
- Adult Calcitonin/*secretion Female Heart Rate/drug effects Humans Kidney Diseases/*physiopathology Male Metoprolol Parathyroid Hormone/*secretion Phosphates/metabolism Propranolol Receptors, Adrenergic/*physiology Receptors, Adrenergic, beta/*physiology Uremia/physiopathology
Coevoet, B., Lambrey, G., de Fremont, J. F., Hardin, J. M., Desplan, C., Calmette, C., Makdassi, R., Andrejak, M., Moukhtar, M. S., & Fournier, A. (1980). Evidence, in uremic man, of the role of beta 2 adrenergic receptors in the secretion of parathyroid hormone and calcitonin (author's transl). Nephrologie, 1(1), 34-6.